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Index > Protein center > F2(Gene name) > Human
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  • F2 (Gene name),
  • Prothrombin (Protein name ),  THRB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    F2;
    Protein name:
    Prothrombin;
    Alternative:
    Coagulation factor II;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    622
    Sequence:
    50:
    MAHVRGLQLP | GCLALAALCS | LVHSQHVFLA | PQQARSLLQR | VRRANTFLEE | 
    100:
    VRKGNLEREC | VEETCSYEEA | FEALESSTAT | DVFWAKYTAC | ETARTPRDKL | 
    150:
    AACLEGNCAE | GLGTNYRGHV | NITRSGIECQ | LWRSRYPHKP | EINSTTHPGA | 
    200:
    DLQENFCRNP | DSSTTGPWCY | TTDPTVRRQE | CSIPVCGQDQ | VTVAMTPRSE | 
    250:
    GSSVNLSPPL | EQCVPDRGQQ | YQGRLAVTTH | GLPCLAWASA | QAKALSKHQD | 
    300:
    FNSAVQLVEN | FCRNPDGDEE | GVWCYVAGKP | GDFGYCDLNY | CEEAVEEETG | 
    350:
    DGLDEDSDRA | IEGRTATSEY | QTFFNPRTFG | SGEADCGLRP | LFEKKSLEDK | 
    400:
    TERELLESYI | DGRIVEGSDA | EIGMSPWQVM | LFRKSPQELL | CGASLISDRW | 
    450:
    VLTAAHCLLY | PPWDKNFTEN | DLLVRIGKHS | RTRYERNIEK | ISMLEKIYIH | 
    500:
    PRYNWRENLD | RDIALMKLKK | PVAFSDYIHP | VCLPDRETAA | SLLQAGYKGR | 
    550:
    VTGWGNLKET | WTANVGKGQP | SVLQVVNLPI | VERPVCKDST | RIRITDNMFC | 
    600:
    AGYKPDEGKR | GDACEGDSGG | PFVMKSPFNN | RWYQMGIVSW | GEGCDRDGKY | 
    622:
    GFYTHVFRLK | KWIQKVIDQF | GE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    String:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Prothrombin
    Cat.:
    E0710h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Prothrombin
    Cat.:
    E0710r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Prothrombin
    Cat.:
    E0710p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Prothrombin
    Cat.:
    E0710b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Prothrombin
    Cat.:
    E0710m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Prothrombin
    Cat.:
    U0710r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Prothrombin
    Cat.:
    U0710h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Prothrombin
    Cat.:
    U0710m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Prothrombin
    Cat.:
    U0710p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Prothrombin
    Cat.:
    U0710b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Prothrombin
    Polyclonal Antibody for Human Prothrombin
    Polyclonal Antibody for Human Prothrombin
    Cat.:
    P0710Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prothrombin
    Cat.:
    P0710Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prothrombin
    Cat.:
    P0710Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Prothrombin
    Monoclonal Antibody for Human Prothrombin
    Monoclonal Antibody for Human Prothrombin
    Monoclonal Antibody for Human Prothrombin
    Monoclonal Antibody for Human Prothrombin
    Protein for Human Prothrombin
    Protein for Human Prothrombin
    Protein for Human Prothrombin
    Protein for Human Prothrombin
    Protein for Human Prothrombin

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Nucleotide sequence of the gene for human prothrombin."
      Degen S.J.F. , Davie E.W.
      Biochemistry26:6165-6177(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Prothrombin Shanghai: hypoprothrombinaemia caused by substitution of Gla29 by Gly."
      Wang W. , Fu Q. , Zhou R. , Wu W. , Ding Q. , Hu Y. , Wang X. , Wang H. , Wang Z.
      Haemophilia10:94-97(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT FA2D GLY-72
      tissue: Blood.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-165
      tissue: Liver.
      tissue: Mammary gland.
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-165
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    7. 7.
      "Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin."
      Degen S.J.F. , McGillivray R.T.A. , Davie E.W.
      Biochemistry22:2087-2097(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-622;GAMMA-CARBOXYGLUTAMATION AT GLU-49; GLU-50; GLU-57; GLU-59; GLU-62; GLU-63; GLU-68; GLU-69; GLU-72 AND GLU-75
    8. 8.
      "Isolation and partial characterization of crystal matrix protein as a potent inhibitor of calcium oxalate crystal aggregation: evidence of activation peptide of human prothrombin."
      Suzuki K. , Moriyama M. , Nakajima C. , Kawamura K. , Miyazawa K. , Tsugawa R. , Kikuchi N. , Nagata K.
      Urol. Res.22:45-50(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 44-64
      tissue: Urine.
    9. 9.
      "Amino acid sequence of human prothrombin fragments 1 and 2."
      Walz D.A. , Hewett-Emmett D. , Seegers W.H.
      Proc. Natl. Acad. Sci. U.S.A.74:1969-1972(1977) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 44-314
    10. 10.
      "Primary structure of human prethrombin 2 and alpha-thrombin."
      Butkowski R.J. , Elion J. , Downing M.R. , Mann K.G.
      J. Biol. Chem.252:4942-4957(1977) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 315-622;GLYCOSYLATION AT ASN-416;VARIANT GLN-532
    11. 11.
      "Antithrombotic thrombin variants."
      Gruber A. , Hanson S.R. , DiCera E.
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 364-622
    12. 12.
      "Mechanism of inhibition of activated protein C by protein C inhibitor."
      Suzuki K. , Nishioka J. , Kusumoto H. , Hashimoto S.
      J. Biochem.95:187-195(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;HETERODIMER WITH SERPINA5
    13. 13.
      "Prothrombin fragment 1 X 2 X 3, a major product of prothrombin activation in human plasma."
      Rabiet M.J. , Blashill A. , Furie B. , Furie B.C.
      J. Biol. Chem.261:13210-13215(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;GAMMA-CARBOXYGLUTAMATION AT GLU-49 AND GLU-50
    14. 14.
      "Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis."
      Glenn K.C. , Frost G.H. , Bergmann J.S. , Carney D.H.
      Pept. Res.1:65-73(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION
    15. 15.
      "Thrombophilic gene mutations and recurrent spontaneous abortion: prothrombin mutation increases the risk in the first trimester."
      Pihusch R. , Buchholz T. , Lohse P. , Rubsamen H. , Rogenhofer N. , Hasbargen U. , Hiller E. , Thaler C.J.
      Am. J. Reprod. Immunol.46:124-131(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RPRGL2 SUSCEPTIBILITY
    16. 16.
      "Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls."
      Casas J.P. , Hingorani A.D. , Bautista L.E. , Sharma P.
      Arch. Neurol.61:1652-1661(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ISCHSTR
    17. 17.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-121 AND ASN-143
      tissue: Plasma.
    18. 18.
      "rhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells."
      Li G. , Cui Y. , McIlmurray L. , Allen W.E. , Wang H.
      J. Orthop. Res.23:680-685(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE TP508 PEPTIDE
    19. 19.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-121; ASN-143 AND ASN-416
      tissue: Plasma.
    20. 20.
      "Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study."
      Fife C. , Mader J.T. , Stone J. , Brill L. , Satterfield K. , Norfleet A. , Zwernemann A. , Ryaby J.T. , Carney D.H.
      Wound Repair Regen.15:23-34(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: THERAPEUTIC USAGE OF THE TP508 PEPTIDE
    21. 21.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416
      tissue: Liver.
    22. 22.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-416
    23. 23.
      "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
      Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416;STRUCTURE OF CARBOHYDRATE
      tissue: Cerebrospinal fluid.
    24. 24.
      "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
      Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-121 AND ASN-143;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
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      "The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment."
      Bode W. , Mayr I. , Baumann U. , Huber R. , Stone S.R. , Hofsteenge J.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) IN COMPLEX WITH HIRUDIN
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH HIRUDIN
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      Priestle J.P. , Rahuel J. , Rink H. , Tones M. , Gruetter M.G.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 328-622 IN COMPLEXES WITH HIRUDIN AND SYNTHETIC INHIBITOR
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      van de Locht A. , Bode W. , Huber R. , le Bonniec B.F. , Stone S.R. , Esmon C.T. , Stubbs M.T.
      EMBO J.16:2977-2984(1997) [PubMed] [Europe PMC] [Abstract]
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    31. 31.
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      "Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate."
      Skordalakes E. , Dodson G.G. , Green D.S. , Goodwin C.A. , Scully M.F. , Hudson H.R. , Kakkar V.V. , Deadman J.J.
      J. Mol. Biol.311:549-555(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 333-621 IN COMPLEX WITH SYNTHETIC INHIBITOR
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      Org. Biomol. Chem.4:2364-2375(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 334-620 IN COMPLEX WITH HIRUDIN AND SYNTHETIC INHIBITOR
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      Liu C.C. , Brustad E. , Liu W. , Schultz P.G.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 334-621 IN COMPLEX WITH HIRUDIN
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      Bioorg. Med. Chem. Lett.18:2062-2066(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 335-621 IN COMPLEX WITH SYNTHETIC INHIBITOR
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 315-622 IN COMPLEX WITH SERPINA5 AND HEPARIN
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA2D LYS-200;PARTIAL PROTEIN SEQUENCE
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      Rabiet M.-J. , Furie B.C. , Furie B.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA2D CYS-314;PROTEIN SEQUENCE OF 310-327
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      "Prothrombin Tokushima, a replacement of arginine-418 by tryptophan that impairs the fibrinogen clotting activity of derived thrombin Tokushima."
      Miyata T. , Morita T. , Inomoto T. , Kawauchi S. , Shirakami A. , Iwanaga S.
      Biochemistry26:1117-1122(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA2D TRP-461;PARTIAL PROTEIN SEQUENCE
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      Blood69:565-569(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA2D TRP-461
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      Henriksen R.A. , Mann K.G.
      Biochemistry27:9160-9165(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA2D CYS-425;PARTIAL PROTEIN SEQUENCE
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      "Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity."
      Henriksen R.A. , Mann K.G.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA2D VAL-601;PARTIAL PROTEIN SEQUENCE
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      "Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity."
      Miyata T. , Aruga R. , Umeyama H. , Bezeaud A. , Guillin M.-C. , Iwanaga S.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA2D ALA-509;PARTIAL PROTEIN SEQUENCE
    44. 44.
      "Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337-->Thr and Arg-388-->His)."
      Morishita E. , Saito M. , Kumabashiri I. , Asakura H. , Matsuda T. , Yamaguchi K.
      Blood80:2275-2280(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA2D THR-380 AND HIS-431
    45. 45.
      "Detection of a single base substitution of the gene for prothrombin Tokushima. The application of PCR-SSCP for the genetic and molecular analysis of dysprothrombinemia."
      Iwahana H. , Yoshimoto K. , Shigekiyo T. , Shirakami A. , Saito S. , Itakura M.
      Int. J. Hematol.55:93-100(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA2D TRP-461
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      "Prothrombin Padua I: incomplete activation due to an amino acid substitution at a factor Xa cleavage site."
      James H.L. , Kim D.J. , Zheng D.-Q. , Girolami A.
      Blood Coagul. Fibrinolysis5:841-844(1994) [PubMed] [Europe PMC] [Abstract]
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    47. 47.
      "Prothrombin Frankfurt: a dysfunctional prothrombin characterized by substitution of Glu-466 by Ala."
      Degen S.J.F. , McDowell S.A. , Sparks L.M. , Scharrer I.
      Thromb. Haemost.73:203-209(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA2D ALA-509
    48. 48.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-165 AND THR-386
    49. 49.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    50. 50.
      "Quantitative detection of single amino acid polymorphisms by targeted proteomics."
      Su Z.D. , Sun L. , Yu D.X. , Li R.X. , Li H.X. , Yu Z.J. , Sheng Q.H. , Lin X. , Zeng R. , Wu J.R.
      J. Mol. Cell Biol.3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-165; LYS-200; THR-386 AND GLN-532;IDENTIFICATION BY MASS SPECTROMETRY
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