Gene name:
TNFRSF1A (TNFR1) ;
Protein name:
Tumor necrosis factor receptor superfamily member 1A ;
Alternative:
Tumor necrosis factor receptor type I (TNF-RI;TNFR-I) ;Tumor necrosis factor receptor 1 (TNF-R1) ;p60 ;p55 ;
CD:
CD120a ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP.
Function:
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MGLPTVPGLL | LPLVLPALLA | DVYPAGVQGL | VPHPGDLEKR | ESPCPQGKYN |
100:
HPQNSTICCT | KCHKGTYLYN | DCPGPGRDTD | CRVCAPGTYT | ALENHLRRCL |
150:
SCSRCRDEMF | QVEISPCVVD | RDTVCGCRKN | QYREYWGETG | FRCLNCSLCP |
200:
NGTVNIPCQE | RQDTICHCHM | GFFLKGAKCI | SCHDCKNKEC | EKLCPTRPST |
250:
GKDSQDPGTT | VLLPLVIVFG | LCLASFASVV | LACRYQRWKP | KLYSIICGQS |
300:
TLVKEGEPEL | LVPAPGFNPT | TTICFSSTPS | SSPVSIPPYI | SCDRSNFGAV |
350:
ASPSSETAPP | HLKAGPILPG | PPASTHLCTP | GPPASTHLCT | PGPPASTHLC |
400:
TPVQKWEASA | PSAPDQLADA | DPATLYAVVD | GVPPSRWKEL | VRRLGLSEHE |
450:
IERLELENGR | HLREAQYSML | AAWRRRTPRR | EATLELLGRV | LRDMDLLGCL |
471:
ENIEEALGGA | ARLASEPRLL | W
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
Pig
ELISA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
ELISA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
ELISA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
ELISA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
ELISA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
CLIA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
CLIA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
CLIA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
CLIA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
CLIA Kit for Bovine Tumor necrosis factor receptor superfamily member 1A
Polyclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Polyclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Polyclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Polyclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Polyclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Monoclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Monoclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Monoclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Monoclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Monoclonal Antibody for Bovine Tumor necrosis factor receptor superfamily member 1A
Protein for Bovine Tumor necrosis factor receptor superfamily member 1A
Protein for Bovine Tumor necrosis factor receptor superfamily member 1A
Protein for Bovine Tumor necrosis factor receptor superfamily member 1A
Protein for Bovine Tumor necrosis factor receptor superfamily member 1A
Protein for Bovine Tumor necrosis factor receptor superfamily member 1A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Aorta .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Uterus .