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Index > Protein center > TNFRSF1A(Gene name) > Human
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  • TNFRSF1A (Gene name),
  • Tumor necrosis factor receptor superfamily member 1A (Protein name ),  TNR1A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (2)
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  • Gene name:
    TNFRSF1A(TNFAR;TNFR1);
    Protein name:
    Tumor necrosis factor receptor superfamily member 1A;
    Alternative:
    Tumor necrosis factor receptor type I(TNF-RI;TNFR-I);Tumor necrosis factor receptor 1(TNF-R1);p60;p55;
    CD:
    CD120a;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein.
    Function:
    Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Secreted
    Protein Attributes:
    Sequence length:
    455
    Sequence:
    50:
    MGLSTVPDLL | LPLVLLELLV | GIYPSGVIGL | VPHLGDREKR | DSVCPQGKYI | 
    100:
    HPQNNSICCT | KCHKGTYLYN | DCPGPGQDTD | CRECESGSFT | ASENHLRHCL | 
    150:
    SCSKCRKEMG | QVEISSCTVD | RDTVCGCRKN | QYRHYWSENL | FQCFNCSLCL | 
    200:
    NGTVHLSCQE | KQNTVCTCHA | GFFLRENECV | SCSNCKKSLE | CTKLCLPQIE | 
    250:
    NVKGTEDSGT | TVLLPLVIFF | GLCLLSLLFI | GLMYRYQRWK | SKLYSIVCGK | 
    300:
    STPEKEGELE | GTTTKPLAPN | PSFSPTPGFT | PTLGFSPVPS | STFTSSSTYT | 
    350:
    PGDCPNFAAP | RREVAPPYQG | ADPILATALA | SDPIPNPLQK | WEDSAHKPQS | 
    400:
    LDTDDPATLY | AVVENVPPLR | WKEFVRRLGL | SDHEIDRLEL | QNGRCLREAQ | 
    450:
    YSMLATWRRR | TPRREATLEL | LGRVLRDMDL | LGCLEDIEEA | LCGPAALPPA | 
    455:
    PSLLR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    UniGene:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1A
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    E0131h
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1A
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    E0131m
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1A
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    E0131r
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1A
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    E0131b
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1A
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    E0131p
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    96T
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    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1A
    Cat.:
    U0131p
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    96T
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    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1A
    Cat.:
    U0131b
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1A
    Cat.:
    U0131h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1A
    Cat.:
    U0131m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1A
    Cat.:
    U0131r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Cat.:
    P0131Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Cat.:
    P0131Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Cat.:
    P0131Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1A
    Protein for Human Tumor necrosis factor receptor superfamily member 1A
    Protein for Human Tumor necrosis factor receptor superfamily member 1A
    Protein for Human Tumor necrosis factor receptor superfamily member 1A
    Protein for Human Tumor necrosis factor receptor superfamily member 1A
    Protein for Human Tumor necrosis factor receptor superfamily member 1A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor."
      Loetscher H. , Pan Y.-C.E. , Lahm H.-W. , Gentz R. , Brockhaus M. , Tabuchi H. , Lesslauer W.
      Cell61:351-359(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Molecular cloning and expression of a receptor for human tumor necrosis factor."
      Schall T.J. , Lewis M. , Koller K.J. , Lee A. , Rice G.C. , Wong G.H.W. , Getanaga T. , Granger G.A. , Lentz R. , Raab H. , Kohr W.J. , Goeddel D.V.
      Cell61:361-370(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    3. 3.
      "Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein."
      Himmler A. , Maurer-Fogy I. , Kroenke M. , Scheurich P. , Pfizenmaier K. , Lantz M. , Olsson I. , Hauptmann R. , Stratowa C. , Adolf G.R.
      DNA Cell Biol.9:705-715(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor."
      Nophar Y. , Kemper O. , Brakebusch C. , Engelmann H. , Zwang R. , Aderka D. , Holtmann H. , Wallach D.
      EMBO J.9:3269-3278(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 41-53; 110-124 AND 199-201 (ISOFORM 1)
    5. 5.
      "Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein."
      Gray P.W. , Barrett K. , Chantry D. , Turner M. , Feldman M.
      Proc. Natl. Acad. Sci. U.S.A.87:7380-7384(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    6. 6.
      "Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13."
      Fuchs P. , Strehl S. , Dworzak M. , Himmler A. , Ambros P.F.
      Genomics13:219-224(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      SeattleSNPs variation discovery resource
      Submitted (2002-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-75 AND GLN-121
    8. 8.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Neutrophil.
      tissue: Teratocarcinoma.
      tissue: Tongue.
      tissue: Uterus.
    9. 9.
      "Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."
      Wang P. , Yu P. , Gao P. , Shi T. , Ma D.
      BMC Genomics10:518-518(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
    10. 10.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
    13. 13.
      "Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis."
      Suzuki J. , Tomizawa S. , Arai H. , Seki Y. , Maruyama K. , Kuroume T.
      Nephron66:386-390(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 41-57 (ISOFORM 1)
      tissue: Urine.
    14. 14.
      "Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors."
      Engelmann H. , Novick D. , Wallach D.
      J. Biol. Chem.265:1531-1536(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 41-45 (ISOFORM 1)
    15. 15.
      "Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis."
      Zhu N. , Khoshnan A. , Schneider R. , Matsumoto M. , Dennert G. , Ware C.F. , Lai M.M.C.
      J. Virol.72:3691-3697(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCV CORE PROTEIN
    16. 16.
      "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation."
      Sanz L. , Sanchez P. , Lallena M.-J. , Diaz-Meco M.T. , Moscat J.
      EMBO J.18:3044-3053(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIPK1 AND SQSTM1
    17. 17.
      "F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis."
      Chan S.-L. , Tan K.-O. , Zhang L. , Yee K.S.Y. , Ronca F. , Chan M.-Y. , Yu V.C.
      J. Biol. Chem.274:32461-32468(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FEM1B
    18. 18.
      "Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I."
      Hildt E. , Oess S.
      J. Exp. Med.189:1707-1714(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2
    19. 19.
      "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains."
      Jiang Y. , Woronicz J.D. , Liu W. , Goeddel D.V.
      Science283:543-546(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAG4
    20. 20.
      "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway."
      Li Q. , Ching A.K.-K. , Chan B.C.-L. , Chow S.K.-Y. , Lim P.-L. , Ho T.C.-Y. , Ip W.-K. , Wong C.-K. , Lam C.W.-K. , Lee K.K.-H. , Chan J.Y.-H. , Chui Y.-L.
      J. Biol. Chem.279:52106-52116(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BRE
    21. 21.
      "The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-alpha signaling."
      Le V.T. , Trilling M. , Hengel H.
      J. Virol.85:13260-13270(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-5 PROTEIN UL138
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MS5;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING (ISOFORM 4)
    23. 23.
      "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation."
      Banner D.W. , D'Arcy A. , Janes W. , Gentz R. , Schoenfeld H.-J. , Broger C. , Loetscher H. , Lesslauer W.
      Cell73:431-445(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 30-211 IN COMPLEX WITH TNFB
    24. 24.
      "Structures of the extracellular domain of the type I tumor necrosis factor receptor."
      Naismith J.H. , Devine T.Q. , Khono H. , Sprang S.R.
      Structure4:1251-1262(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 41-202
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FHF ARG-59; TYR-62; MET-79; PHE-81; ARG-117 AND TYR-117
    26. 26.
      "A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family."
      Dode C. , Papo T. , Fieschi C. , Pecheux C. , Dion E. , Picard F. , Godeau P. , Bienvenu J. , Piette J.-C. , Delpech M. , Grateau G.
      Arthritis Rheum.43:1535-1542(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHF SER-59
    27. 27.
      "The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers."
      Aksentijevich I. , Galon J. , Soares M. , Mansfield E. , Hull K. , Oh H.-H. , Goldbach-Mansky R. , Dean J. , Athreya B. , Reginato A.J. , Henrickson M. , Pons-Estel B. , O'Shea J.J. , Kastner D.L.
      Am. J. Hum. Genet.69:301-314(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FHF GLN-51; SER-59; GLY-62; LEU-75; GLY-115 AND GLN-121
    28. 28.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FHF SER-99 AND PRO-121
    29. 29.
      "Tumour necrosis factor receptor-associated periodic syndrome with a novel mutation in the TNFRSF1A gene in a Japanese family."
      Kusuhara K. , Nomura A. , Nakao F. , Hara T.
      Eur. J. Pediatr.163:30-32(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHF SER-99
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