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Index > Protein center > TNFRSF8(Gene name) > Human
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  • TNFRSF8 (Gene name),
  • Tumor necrosis factor receptor superfamily member 8 (Protein name ),  TNR8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TNFRSF8(CD30;D1S166E);
    Protein name:
    Tumor necrosis factor receptor superfamily member 8;
    Alternative:
    Lymphocyte activation antigen CD30;CD30L receptor;Ki-1 antigen;
    CD:
    CD30;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
    Function:
    Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
    Subcellular Location:
    Isoform Short Cytoplasm
    Protein Attributes:
    Sequence length:
    595
    Sequence:
    50:
    MRVLLAALGL | LFLGALRAFP | QDRPFEDTCH | GNPSHYYDKA | VRRCCYRCPM | 
    100:
    GLFPTQQCPQ | RPTDCRKQCE | PDYYLDEADR | CTACVTCSRD | DLVEKTPCAW | 
    150:
    NSSRVCECRP | GMFCSTSAVN | SCARCFFHSV | CPAGMIVKFP | GTAQKNTVCE | 
    200:
    PASPGVSPAC | ASPENCKEPS | SGTIPQAKPT | PVSPATSSAS | TMPVRGGTRL | 
    250:
    AQEAASKLTR | APDSPSSVGR | PSSDPGLSPT | QPCPEGSGDC | RKQCEPDYYL | 
    300:
    DEAGRCTACV | SCSRDDLVEK | TPCAWNSSRT | CECRPGMICA | TSATNSCARC | 
    350:
    VPYPICAAET | VTKPQDMAEK | DTTFEAPPLG | TQPDCNPTPE | NGEAPASTSP | 
    400:
    TQSLLVDSQA | SKTLPIPTSA | PVALSSTGKP | VLDAGPVLFW | VILVLVVVVG | 
    450:
    SSAFLLCHRR | ACRKRIRQKL | HLCYPVQTSQ | PKLELVDSRP | RRSSTQLRSG | 
    500:
    ASVTEPVAEE | RGLMSQPLME | TCHSVGAAYL | ESLPLQDASP | AGGPSSPRDL | 
    550:
    PEPRVSTEHT | NNKIEKIYIM | KADTVIVGTV | KAELPEGRGL | AGPAEPELEE | 
    595:
    ELEADHTPHY | PEQETEPPLG | SCSDVMLSVE | EEGKEDPLPT | AASGK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    String:
    UniGene:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 8
    Cat.:
    E0020h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 8
    Cat.:
    E0020m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 8
    Cat.:
    E0020r
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 8
    Cat.:
    U0020r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 8
    Cat.:
    U0020m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 8
    Cat.:
    U0020h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 8
    Cat.:
    P0020Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 8
    Cat.:
    P0020Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 8
    Cat.:
    P0020Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 8
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 8
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 8
    Protein for Human Tumor necrosis factor receptor superfamily member 8
    Protein for Human Tumor necrosis factor receptor superfamily member 8
    Protein for Human Tumor necrosis factor receptor superfamily member 8

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    Linearity
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    References
    1. 1.
      "Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease."
      Duerkop H. , Latza U. , Hummel M. , Eitelbach F. , Seed B. , Stein H.
      Cell68:421-427(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Lymphoid tissue.
    2. 2.
      "Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources."
      Jung W. , Krueger S. , Renner C. , Gause A. , Sahin U. , Trumper L. , Pfreundschuh M.
      Mol. Immunol.31:1329-1334(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages."
      Horie R. , Ito K. , Tatewaki M. , Nagai M. , Aizawa S. , Higashihara M. , Ishida T. , Inoue J. , Takizawa H. , Watanabe T.
      Blood88:2422-2432(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    4. 4.
      "Structure of the Hodgkin's disease associated human CD30 gene and the influence of a microsatellite region on its expression in CD30+ cell lines."
      Durkop H. , Oberbarnscheidt M. , Latza U. , Bulfone-Paus S.
      Submitted (2000-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 1)
      tissue: Placenta.
    5. 5.
      NIEHS SNPs program
      Submitted (2003-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS TYR-273 AND GLY-402
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-297
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Blood.
      tissue: Testis.
    8. 8.
      "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors."
      Lee S.Y. , Park C.G. , Choi Y.
      J. Exp. Med.183:669-674(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF1 AND TRAF2
    9. 9.
      "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily."
      Boucher L.-M. , Marengere L.E. , Lu Y. , Thukral S. , Mak T.W.
      Biochem. Biophys. Res. Commun.233:592-600(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF3
    10. 10.
      "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)."
      Mizushima S. , Fujita M. , Ishida T. , Azuma S. , Kato K. , Hirai M. , Otsuka M. , Yamamoto T. , Inoue J.
      Gene207:135-140(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF5
    11. 11.
      "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation."
      Aizawa S. , Nakano H. , Ishida T. , Horie R. , Nagai M. , Ito K. , Yagita H. , Okumura K. , Inoue J. , Watanabe T.
      J. Biol. Chem.272:2042-2045(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF5
    12. 12.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    13. 13.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "The structural basis for the recognition of diverse receptor sequences by TRAF2."
      Ye H. , Park Y.C. , Kreishman M. , Kieff E. , Wu H.
      Mol. Cell4:321-330(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 576-583 IN COMPLEX WITH TRAF2;INTERACTION WITH TRAF2
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