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Index > Protein center > TRPM2(Gene name) > Human
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  • TRPM2 (Gene name),
  • Transient receptor potential cation channel subfamily M member 2 (Protein name ),  TRPM2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TRPM2(EREG1;KNP3;LTRPC2;TRPC7);
    Protein name:
    Transient receptor potential cation channel subfamily M member 2;
    Alternative:
    Long transient receptor potential channel 2(LTrpC-2;LTrpC2);Estrogen-responsive element-associated gene 1 protein;Transient receptor potential channel 7(TrpC7);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.
    Function:
    Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1503
    Sequence:
    50:
    MEPSALRKAG | SEQEEGFEGL | PRRVTDLGMV | SNLRRSNSSL | FKSWRLQCPF | 
    100:
    GNNDKQESLS | SWIPENIKKK | ECVYFVESSK | LSDAGKVVCQ | CGYTHEQHLE | 
    150:
    EATKPHTFQG | TQWDPKKHVQ | EMPTDAFGDI | VFTGLSQKVK | KYVRVSQDTP | 
    200:
    SSVIYHLMTQ | HWGLDVPNLL | ISVTGGAKNF | NMKPRLKSIF | RRGLVKVAQT | 
    250:
    TGAWIITGGS | HTGVMKQVGE | AVRDFSLSSS | YKEGELITIG | VATWGTVHRR | 
    300:
    EGLIHPTGSF | PAEYILDEDG | QGNLTCLDSN | HSHFILVDDG | THGQYGVEIP | 
    350:
    LRTRLEKFIS | EQTKERGGVA | IKIPIVCVVL | EGGPGTLHTI | DNATTNGTPC | 
    400:
    VVVEGSGRVA | DVIAQVANLP | VSDITISLIQ | QKLSVFFQEM | FETFTESRIV | 
    450:
    EWTKKIQDIV | RRRQLLTVFR | EGKDGQQDVD | VAILQALLKA | SRSQDHFGHE | 
    500:
    NWDHQLKLAV | AWNRVDIARS | EIFMDEWQWK | PSDLHPTMTA | ALISNKPEFV | 
    550:
    KLFLENGVQL | KEFVTWDTLL | YLYENLDPSC | LFHSKLQKVL | VEDPERPACA | 
    600:
    PAAPRLQMHH | VAQVLRELLG | DFTQPLYPRP | RHNDRLRLLL | PVPHVKLNVQ | 
    650:
    GVSLRSLYKR | SSGHVTFTMD | PIRDLLIWAI | VQNRRELAGI | IWAQSQDCIA | 
    700:
    AALACSKILK | ELSKEEEDTD | SSEEMLALAE | EYEHRAIGVF | TECYRKDEER | 
    750:
    AQKLLTRVSE | AWGKTTCLQL | ALEAKDMKFV | SHGGIQAFLT | KVWWGQLSVD | 
    800:
    NGLWRVTLCM | LAFPLLLTGL | ISFREKRLQD | VGTPAARARA | FFTAPVVVFH | 
    850:
    LNILSYFAFL | CLFAYVLMVD | FQPVPSWCEC | AIYLWLFSLV | CEEMRQLFYD | 
    900:
    PDECGLMKKA | ALYFSDFWNK | LDVGAILLFV | AGLTCRLIPA | TLYPGRVILS | 
    950:
    LDFILFCLRL | MHIFTISKTL | GPKIIIVKRM | MKDVFFFLFL | LAVWVVSFGV | 
    1000:
    AKQAILIHNE | RRVDWLFRGA | VYHSYLTIFG | QIPGYIDGVN | FNPEHCSPNG | 
    1050:
    TDPYKPKCPE | SDATQQRPAF | PEWLTVLLLC | LYLLFTNILL | LNLLIAMFNY | 
    1100:
    TFQQVQEHTD | QIWKFQRHDL | IEEYHGRPAA | PPPFILLSHL | QLFIKRVVLK | 
    1150:
    TPAKRHKQLK | NKLEKNEEAA | LLSWEIYLKE | NYLQNRQFQQ | KQRPEQKIED | 
    1200:
    ISNKVDAMVD | LLDLDPLKRS | GSMEQRLASL | EEQVAQTAQA | LHWIVRTLRA | 
    1250:
    SGFSSEADVP | TLASQKAAEE | PDAEPGGRKK | TEEPGDSYHV | NARHLLYPNC | 
    1300:
    PVTRFPVPNE | KVPWETEFLI | YDPPFYTAER | KDAAAMDPMG | DTLEPLSTIQ | 
    1350:
    YNVVDGLRDR | RSFHGPYTVQ | AGLPLNPMGR | TGLRGRGSLS | CFGPNHTLYP | 
    1400:
    MVTRWRRNED | GAICRKSIKK | MLEVLVVKLP | LSEHWALPGG | SREPGEMLPR | 
    1450:
    KLKRILRQEH | WPSFENLLKC | GMEVYKGYMD | DPRNTDNAWI | ETVAVSVHFQ | 
    1500:
    DQNDVELNRL | NSNLHACDSG | ASIRWQVVDR | RIPLYANHKT | LLQKAAAEFG | 
    1503:
    AHY
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    Pfam:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Transient receptor potential cation channel subfamily M member 2
    ELISA Kit for Human Transient receptor potential cation channel subfamily M member 2
    CLIA Kit for Human Transient receptor potential cation channel subfamily M member 2
    CLIA Kit for Human Transient receptor potential cation channel subfamily M member 2
    Polyclonal Antibody for Human Transient receptor potential cation channel subfamily M member 2
    Polyclonal Antibody for Human Transient receptor potential cation channel subfamily M member 2
    Monoclonal Antibody for Human Transient receptor potential cation channel subfamily M member 2
    Monoclonal Antibody for Human Transient receptor potential cation channel subfamily M member 2
    Protein for Human Transient receptor potential cation channel subfamily M member 2
    Protein for Human Transient receptor potential cation channel subfamily M member 2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain."
      Nagamine K. , Kudoh J. , Minoshima S. , Kawasaki K. , Asakawa S. , Ito F. , Shimizu N.
      Genomics54:124-131(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-1189
      tissue: Brain.
    2. 2.
      "Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose."
      Wehage E. , Eisfeld J. , Heiner I. , Juengling E. , Zitt C. , Lueckhoff A.
      J. Biol. Chem.277:23150-23156(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT ARG-1189;REGULATION BY OXIDATIVE STRESS
      tissue: Promyelocytic leukemia.
    3. 3.
      "A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death."
      Zhang W. , Chu X. , Tong Q. , Cheung J.Y. , Conrad K. , Masker K. , Miller B.A.
      J. Biol. Chem.278:16222-16229(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);VARIANT ARG-1189;INTERACTION BETWEEN ISOFORMS 1 AND 3;SUBCELLULAR LOCATION
      tissue: Bone marrow.
    4. 4.
      "Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum."
      Uemura T. , Kudoh J. , Noda S. , Kanba S. , Shimizu N.
      Biochem. Biophys. Res. Commun.328:1232-1243(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-1189
      tissue: Brain.
    5. 5.
      "Cloning of the human TRPM2."
      Hayes P.D.
      Submitted (2005-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-1189
    6. 6.
      NIEHS SNPs program
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-52; ILE-166; MET-385; GLU-543; GLU-780; TRP-1199; GLY-1201; SER-1249; MET-1347; LYS-1359; MET-1368 AND SER-1438
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 9.
      "Molecular cloning of a novel estrogen responsive gene, estrogen responsive element associated gene 1 (EREG1), which contains MutT like domain."
      Hiroi H. , Muramatsu M. , Inoue S.
      Submitted (1998-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1190-1503
    9. 10.
      "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology."
      Perraud A.-L. , Fleig A. , Dunn C.A. , Bagley L.A. , Launay P. , Schmitz C. , Stokes A.J. , Zhu Q. , Bessman M.J. , Penner R. , Kinet J.-P. , Scharenberg A.M.
      Nature411:595-599(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;REGULATION BY ADP-RIBOSE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY PYRIMIDINE NUCLEOTIDES;TISSUE SPECIFICITY
    11. 12.
      "LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death."
      Hara Y. , Wakamori M. , Ishii M. , Maeno E. , Nishida M. , Yoshida T. , Yamada H. , Shimizu S. , Mori E. , Kudoh J. , Shimizu N. , Kurose H. , Okada Y. , Imoto K. , Mori Y.
      Mol. Cell9:163-173(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF MET-1397
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