Protein name:
Thioredoxin-interacting protein ;
Alternative:
Vitamin D3 up-regulated protein 1 ;Thioredoxin-binding protein 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains).
Function:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MVMFKKIKSF | EVVFNDPEKV | YGSGEKVAGR | VIVEVCEVTR | VKAVRILACG |
100:
VAKVLWMQGS | QQCKQTSEYL | RYEDTLLLED | QPTGENEMVI | MRPGNKYEYK |
150:
FGFELPQGPL | GTSFKGKYGC | VDYWVKAFLD | RPSQPTQETK | KNFEVVDLVD |
200:
VNTPDLMAPV | SAKKEKKVSC | MFIPDGRVSV | SARIDRKGFC | EGDEISIHAD |
250:
FENTCSRIVV | PKAAIVARHT | YLANGQTKVL | TQKLSSVRGN | HIISGTCASW |
300:
RGKSLRVQKI | RPSILGCNIL | RVEYSLLIYV | SVPGSKKVIL | DLPLVIGSRS |
350:
GLSSRTSSMA | SRTSSEMSWV | DLNIPDTPEA | PPCYMDVIPE | DHRLESPTTP |
391:
LLDDMDGSQD | SPIFMYAPEF | KFMPPPTYTE | VDPCILNNNV | Q
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
Pig
ELISA Kit for Human Thioredoxin-interacting protein
ELISA Kit for Human Thioredoxin-interacting protein
ELISA Kit for Human Thioredoxin-interacting protein
ELISA Kit for Human Thioredoxin-interacting protein
CLIA Kit for Human Thioredoxin-interacting protein
CLIA Kit for Human Thioredoxin-interacting protein
CLIA Kit for Human Thioredoxin-interacting protein
CLIA Kit for Human Thioredoxin-interacting protein
Polyclonal Antibody for Human Thioredoxin-interacting protein
Polyclonal Antibody for Human Thioredoxin-interacting protein
Polyclonal Antibody for Human Thioredoxin-interacting protein
Polyclonal Antibody for Human Thioredoxin-interacting protein
Monoclonal Antibody for Human Thioredoxin-interacting protein
Monoclonal Antibody for Human Thioredoxin-interacting protein
Monoclonal Antibody for Human Thioredoxin-interacting protein
Monoclonal Antibody for Human Thioredoxin-interacting protein
Protein for Human Thioredoxin-interacting protein
Protein for Human Thioredoxin-interacting protein
Protein for Human Thioredoxin-interacting protein
Protein for Human Thioredoxin-interacting protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Uterus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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J. Biol. Chem.285:8869-8879(2010)
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[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ITCH;UBIQUITINATION BY ITCH
12.
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Sci. Signal.3:RA3-RA3(2010)
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[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
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Oncogene30:3792-3801(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DDIT4
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 2-149;SUBUNIT;INTERCHAIN DISULFIDE BOND