Protein name:
Thioredoxin-interacting protein ;
Alternative:
Vitamin D3 up-regulated protein 1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (By similarity). Interacts (via C-terminus) with ITCH (via WW domains).
Function:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MVMFKKIKSF | EVVFNDPEKV | YGSGEKVAGR | VTVEVCEVTR | VKAVRILACG |
100:
VAKVLWMQGS | QQCKQTLDYL | RYEDTLLLED | QPTGENEMVI | MRPGNKYEYK |
150:
FGFELPQGPL | GTSFKGKYGC | VDYWVKAFLD | RPSQPTQEAK | KNFEVMDLVD |
200:
VNTPDLMAPV | SAKKEKKVSC | MFIPDGRVSV | SARIDRKGFC | EGDDISIHAD |
250:
FENTCSRIVV | PKAAIVARHT | YLANGQTKVL | TQKLSSVRGN | HIISGTCASW |
300:
RGKSLRVQKI | RPSILGCNIL | RVEYSLLIYV | SVPGSKKVIL | DLPLVIGSRS |
350:
GLSSRTSSMA | SRTSSEMSWI | DLNIPDTPEA | PPCYMDVIPE | DHRLESPTTP |
394:
LLDDVDDSQD | SPIFMYAPEF | QFMPPPTYTE | VDPCVLNNNN | NNVQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
Pig
ELISA Kit for Rat Thioredoxin-interacting protein
ELISA Kit for Rat Thioredoxin-interacting protein
ELISA Kit for Rat Thioredoxin-interacting protein
ELISA Kit for Rat Thioredoxin-interacting protein
CLIA Kit for Rat Thioredoxin-interacting protein
CLIA Kit for Rat Thioredoxin-interacting protein
CLIA Kit for Rat Thioredoxin-interacting protein
CLIA Kit for Rat Thioredoxin-interacting protein
Polyclonal Antibody for Rat Thioredoxin-interacting protein
Polyclonal Antibody for Rat Thioredoxin-interacting protein
Polyclonal Antibody for Rat Thioredoxin-interacting protein
Polyclonal Antibody for Rat Thioredoxin-interacting protein
Monoclonal Antibody for Rat Thioredoxin-interacting protein
Monoclonal Antibody for Rat Thioredoxin-interacting protein
Monoclonal Antibody for Rat Thioredoxin-interacting protein
Monoclonal Antibody for Rat Thioredoxin-interacting protein
Protein for Rat Thioredoxin-interacting protein
Protein for Rat Thioredoxin-interacting protein
Protein for Rat Thioredoxin-interacting protein
Protein for Rat Thioredoxin-interacting protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Heart .