UBE2B ELISA Kit for Human(Homo sapiens) | EIAab.comUBE2B ELISA Kit for Human(Homo sapiens)

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UBE2B (Gene name),

Ubiquitin-conjugating enzyme E2 B (Protein name ), UBE2B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UBE2B(RAD6B);

Protein name:

Ubiquitin-conjugating enzyme E2 B;

Alternative:

Ubiquitin carrier protein B;RAD6 homolog B(HR6B;hHR6B);Ubiquitin-protein ligase B;Ubiquitin-conjugating enzyme E2-17 kDa;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with RAD18, UBR2 and WAC.

Function:

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.

Subcellular Location:

Cell membrane Nucleus In peripheral neurons, expressed both at the plasma membrane and in nuclei.

Protein Attributes:

Sequence length:

152

Sequence:

50:

100:

150:

152:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P63146

KEGG:

hsa:7320

SMR:

P63146

UniGene:

Hs.612096

Pfam:

PF00179

MIM:

179095

STRING:

9606.ENSP00000265339

Uniprot:

P63146

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ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B

Cat.:

E1063h

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96T

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ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B

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E1063r

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96T

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ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B

Cat.:

E1063b

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96T

ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B

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E1063m

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96T

ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B

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CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B

Cat.:

U1063r

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96T

CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B

Cat.:

U1063b

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Packing:

96T

CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B

Cat.:

U1063h

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Packing:

96T

CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B

Cat.:

U1063m

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MSDS:

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Packing:

96T

CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B

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Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B

Cat.:

P1063Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B

Cat.:

P1063Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B

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P1063Rb-h

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Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B

Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B

Protein for Human Ubiquitin-conjugating enzyme E2 B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6."
Schneider R. , Eckerskorn C. , Lottspeich F. , Schweiger M.
EMBO J.9:1431-1435(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue: Placenta.
2.

"Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6."
Woffendin C. , Chen Z.Y. , Staskus K. , Retzel E.F. , Plagemann P.G.
Biochim. Biophys. Acta1090:81-85(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
3.

"Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6."
Koken M.H.M. , Reynolds P. , Jaspers-Dekker I. , Prakash L. , Prakash S. , Bootsma D. , Hoeijmakers J.H.J.
Proc. Natl. Acad. Sci. U.S.A.88:8865-8869(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
7.

NIEHS SNPs program
Submitted (2005-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Bone marrow.
tissue: Brain.
10.

"The human RAD18 gene product interacts with HHR6A and HHR6B."
Xin H. , Lin W. , Sumanasekera W. , Zhang Y. , Wu X. , Wang Z.
Nucleic Acids Res.28:2847-2854(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD18
11.

"The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions."
Kim J. , Hake S.B. , Roeder R.G.
Mol. Cell20:759-770(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination."
Motegi A. , Sood R. , Moinova H. , Markowitz S.D. , Liu P.P. , Myung K.
J. Cell Biol.175:703-708(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen."
Unk I. , Hajdu I. , Fatyol K. , Szakal B. , Blastyak A. , Bermudez V. , Hurwitz J. , Prakash L. , Prakash S. , Haracska L.
Proc. Natl. Acad. Sci. U.S.A.103:18107-18112(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."
David Y. , Ziv T. , Admon A. , Navon A.
J. Biol. Chem.285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription."
Zhang F. , Yu X.
Mol. Cell41:384-397(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WAC
16.

"The NMR structure of the class I human ubiquitin-conjugating enzyme 2b."
Miura T. , Klaus W. , Ross A. , Guntert P. , Senn H.
J. Biomol. NMR22:89-92(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR

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