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Index > Protein center > Axl(Gene name) > Mouse
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  • Axl (Gene name),
  • Tyrosine-protein kinase receptor UFO (Protein name ),  UFO_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Axl(Ark;Ufo);
    Protein name:
    Tyrosine-protein kinase receptor UFO;
    Alternative:
    Adhesion-related kinase;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer and heterotetramer with ligand GAS6 (By similarity). Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TENC1.
    Function:
    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitement of GRB2 and phosphatidylinositol-3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    888
    Sequence:
    50:
    MGRVPLAWWL | ALCCWGCAAH | KDTQTEAGSP | FVGNPGNITG | ARGLTGTLRC | 
    100:
    ELQVQGEPPE | VVWLRDGQIL | ELADNTQTQV | PLGEDWQDEW | KVVSQLRISA | 
    150:
    LQLSDAGEYQ | CMVHLEGRTF | VSQPGFVGLE | GLPYFLEEPE | DKAVPANTPF | 
    200:
    NLSCQAQGPP | EPVTLLWLQD | AVPLAPVTGH | SSQHSLQTPG | LNKTSSFSCE | 
    250:
    AHNAKGVTTS | RTATITVLPQ | RPHHLHVVSR | QPTELEVAWT | PGLSGIYPLT | 
    300:
    HCNLQAVLSD | DGVGIWLGKS | DPPEDPLTLQ | VSVPPHQLRL | EKLLPHTPYH | 
    350:
    IRISCSSSQG | PSPWTHWLPV | ETTEGVPLGP | PENVSAMRNG | SQVLVRWQEP | 
    400:
    RVPLQGTLLG | YRLAYRGQDT | PEVLMDIGLT | REVTLELRGD | RPVANLTVSV | 
    450:
    TAYTSAGDGP | WSLPVPLEPW | RPGQGQPLHH | LVSEPPPRAF | SWPWWYVLLG | 
    500:
    ALVAAACVLI | LALFLVHRRK | KETRYGEVFE | PTVERGELVV | RYRVRKSYSR | 
    550:
    RTTEATLNSL | GISEELKEKL | RDVMVDRHKV | ALGKTLGEGE | FGAVMEGQLN | 
    600:
    QDDSILKVAV | KTMKIAICTR | SELEDFLSEA | VCMKEFDHPN | VMRLIGVCFQ | 
    650:
    GSDREGFPEP | VVILPFMKHG | DLHSFLLYSR | LGDQPVFLPT | QMLVKFMADI | 
    700:
    ASGMEYLSTK | RFIHRDLAAR | NCMLNENMSV | CVADFGLSKK | IYNGDYYRQG | 
    750:
    RIAKMPVKWI | AIESLADRVY | TSKSDVWSFG | VTMWEIATRG | QTPYPGVENS | 
    800:
    EIYDYLRQGN | RLKQPVDCLD | GLYALMSRCW | ELNPRDRPSF | AELREDLENT | 
    850:
    LKALPPAQEP | DEILYVNMDE | GGSHLEPRGA | AGGADPPTQP | DPKDSCSCLT | 
    888:
    AADVHSAGRY | VLCPSTAPGP | TLSADRGCPA | PPGQEDGA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Tyrosine-protein kinase receptor UFO
    Cat.:
    E2483h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Tyrosine-protein kinase receptor UFO
    Cat.:
    E2483m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tyrosine-protein kinase receptor UFO
    Cat.:
    U2483h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tyrosine-protein kinase receptor UFO
    Cat.:
    U2483m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Tyrosine-protein kinase receptor UFO
    Cat.:
    P2483Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tyrosine-protein kinase receptor UFO
    Cat.:
    P2483Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Tyrosine-protein kinase receptor UFO
    Monoclonal Antibody for Mouse Tyrosine-protein kinase receptor UFO
    Protein for Mouse Tyrosine-protein kinase receptor UFO
    Protein for Mouse Tyrosine-protein kinase receptor UFO

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The murine ufo receptor: molecular cloning, chromosomal localization and in situ expression analysis."
      Faust M. , Ebensperger C. , Schulz A.S. , Schleithoff L. , Hameister H. , Bartram C.R. , Janssen J.W.G.
      Oncogene7:1287-1293(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: CD-1.
      tissue: Heart.
    2. 2.
      "A putative receptor tyrosine kinase with unique structural topology."
      Rescigno J. , Mansukhani A. , Basilico C.
      Oncogene6:1909-1913(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
      tissue: Dendritic cell.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
      tissue: Eye.
    6. 6.
      "The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases."
      Stitt T.N. , Conn G. , Gore M. , Lai C. , Bruno J. , Radziejewski C. , Mattsson K. , Fisher J. , Gies D.R. , Jones P.F. , Masiakowski P. , Ryan T.E. , Tobkes N.J. , Chen D.H. , DiStefano P.S. , Long G.L. , Basilico C. , Goldfarb M.P. , more...
      Cell80:661-670(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIGAND GAS6
    7. 7.
      "TAM receptors are pleiotropic inhibitors of the innate immune response."
      Rothlin C.V. , Ghosh S. , Zuniga E.I. , Oldstone M.B. , Lemke G.
      Cell131:1124-1136(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INNATE IMMUNE RESPONSE INHIBITION
    8. 8.
      "Sertoli cell-initiated testicular innate immune response through toll-like receptor-3 activation is negatively regulated by Tyro3, Axl, and mer receptors."
      Sun B. , Qi N. , Shang T. , Wu H. , Deng T. , Han D.
      Endocrinology151:2886-2897(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INNATE IMMUNE RESPONSE INHIBITION
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