Kdr ELISA Kit for Mouse(Mus musculus) | EIAab.comKdr ELISA Kit for Mouse(Mus musculus)

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Kdr (Gene name),

Vascular endothelial growth factor receptor 2 (Protein name ), VGFR2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Kdr(Flk-1;Flk1);

Protein name:

Vascular endothelial growth factor receptor 2(VEGFR-2);

Alternative:

Kinase NYK;Fetal liver kinase 1(FLK-1);Protein-tyrosine kinase receptor flk-1;

CD:

CD309;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SHB; upon VEGF activation. Interacts with MYOF.

Function:

Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1367

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1367:

PVPAPPPTPG | NHERGAA

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

UniGene:

Mm.285

Pfam:

PF07679

String:

P35918

SMR:

P35918

Uniprot:

P35918

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ELISA Kit for Mouse VEGFR-2

Cat.:

E0148h

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse VEGFR-2

Cat.:

E0148r

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Looking for manual.

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Packing:

96T

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ELISA Kit for Mouse VEGFR-2

Cat.:

E0148m

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96T

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CLIA Kit for Mouse VEGFR-2

Cat.:

U0148m

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Looking for manual.

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Packing:

96T

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CLIA Kit for Mouse VEGFR-2

Cat.:

U0148r

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Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse VEGFR-2

Cat.:

U0148h

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Packing:

96T

Polyclonal Antibody for Mouse VEGFR-2

Cat.:

P0148Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse VEGFR-2

Cat.:

P0148Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse VEGFR-2

Cat.:

P0148Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse VEGFR-2

Protein for Mouse VEGFR-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis."
Millauer B. , Wizigmann-Voos S. , Schnurch H. , Martinez R. , Mueller N.P.H. , Risau W. , Ullrich A.
Cell72:835-846(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH VEGFA
strain: BALB/c.
tissue: Embryo.
2.

"A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit."
Mathews W. , Jordan C.T. , Gavin M. , Jenkins N.A. , Copeland N.G. , Lemishcka I.R.
Proc. Natl. Acad. Sci. U.S.A.88:9026-9030(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
strain: C3H/He.
tissue: Fetal liver.
3.

"NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo."
Oelrichs R.B. , Reid H.H. , Bernard O. , Ziemiecki A. , Wilks A.F.
Oncogene8:11-18(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
4.

"Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth."
Albuquerque R.J. , Hayashi T. , Cho W.G. , Kleinman M.E. , Dridi S. , Takeda A. , Baffi J.Z. , Yamada K. , Kaneko H. , Green M.G. , Chappell J. , Wilting J. , Weich H.A. , Yamagami S. , Amano S. , Mizuki N. , Alexander J.S. , Peterson M.L. , more...
Nat. Med.15:1023-1030(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH VEGFC;FUNCTION IN INHIBITING VEGFC SIGNALING;SUBCELLULAR LOCATION
strain: C57BL/6.
5.

"Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor."
Patterson C. , Perrella M.A. , Hsieh C.-M. , Yoshizumi M. , Lee M.-E. , Harber E.
J. Biol. Chem.270:23111-23118(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15
6.

"Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium."
Quinn T.P. , Peters K.G. , de Vries C. , Ferrara N. , Williams L.T.
Proc. Natl. Acad. Sci. U.S.A.90:7533-7537(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH VEGFA;AUTOPHOSPHORYLATION;TISSUE SPECIFICITY
7.

"Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice."
Shalaby F. , Rossant J. , Yamaguchi T.P. , Gertsenstein M. , Wu X.F. , Breitman M.L. , Schuh A.C.
Nature376:62-66(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
8.

"Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution."
Pepper M.S. , Baetens D. , Mandriota S.J. , Di Sanza C. , Oikemus S. , Lane T.F. , Soriano J.V. , Montesano R. , Iruela-Arispe M.L.
Dev. Dyn.218:507-524(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
9.

"The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules."
Meyer R.D. , Dayanir V. , Majnoun F. , Rahimi N.
J. Biol. Chem.277:27081-27087(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-1212;MUTAGENESIS OF TYR-1212
10.

"Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites."
Dixelius J. , Makinen T. , Wirzenius M. , Karkkainen M.J. , Wernstedt C. , Alitalo K. , Claesson-Welsh L.
J. Biol. Chem.278:40973-40979(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLT4;CATALYTIC ACTIVITY
11.

"Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1."
Autiero M. , Waltenberger J. , Communi D. , Kranz A. , Moons L. , Lambrechts D. , Kroll J. , Plaisance S. , De Mol M. , Bono F. , Kliche S. , Fellbrich G. , Ballmer-Hofer K. , Maglione D. , Mayr-Beyrle U. , Dewerchin M. , Dombrowski S. , Stanimirovic D. , more...
Nat. Med.9:936-943(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLT1
12.

"The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration."
Holmqvist K. , Cross M.J. , Rolny C. , Haegerkvist R. , Rahimi N. , Matsumoto T. , Claesson-Welsh L. , Welsh M.
J. Biol. Chem.279:22267-22275(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB;MUTAGENESIS OF TYR-1173
13.

"The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation."
Singh A.J. , Meyer R.D. , Band H. , Rahimi N.
Mol. Biol. Cell16:2106-2118(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CBL;UBIQUITINATION;PHOSPHORYLATION AT TYR-1052 AND TYR-1057;MUTAGENESIS OF LYS-866; SER-1188 AND SER-1191;SUBCELLULAR LOCATION
14.

"Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function."
Bernatchez P.N. , Acevedo L. , Fernandez-Hernando C. , Murata T. , Chalouni C. , Kim J. , Erdjument-Bromage H. , Shah V. , Gratton J.-P. , McNally E.M. , Tempst P. , Sessa W.C.
J. Biol. Chem.282:30745-30753(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYOF
15.

"Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1."
Kanemura H. , Satoh T. , Bilasy S.E. , Ueda S. , Hirashima M. , Kataoka T.
Biochem. Biophys. Res. Commun.387:754-759(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
16.

"Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression."
Facemire C.S. , Nixon A.B. , Griffiths R. , Hurwitz H. , Coffman T.M.
Hypertension54:652-658(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis."
Nakao S. , Zandi S. , Hata Y. , Kawahara S. , Arita R. , Schering A. , Sun D. , Melhorn M.I. , Ito Y. , Lara-Castillo N. , Ishibashi T. , Hafezi-Moghadam A.
Blood117:1081-1090(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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