Protein name:
von Willebrand factor (vWF) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Multimeric. Interacts with F8.
Function:
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Subcellular Location:
Secreted
Secreted
extracellular space
extracellular matrix
Localized to storage granules.
Protein Attributes:
50:
MIPARFAGVL | LALALILPGT | LCAEGTRGRS | STARCSLFGS | DFVNTFDGSM |
100:
YSFAGYCSYL | LAGGCQKRSF | SIIGDFQNGK | RVSLSVYLGE | FFDIHLFVNG |
150:
TVTQGDQRVS | MPYASKGLYL | ETEAGYYKLS | GEAYGFVARI | DGSGNFQVLL |
200:
SDRYFNKTCG | LCGNFNIFAE | DDFMTQEGTL | TSDPYDFANS | WALSSGEQWC |
250:
ERASPPSSSC | NISSGEMQKG | LWEQCQLLKS | TSVFARCHPL | VDPEPFVALC |
300:
EKTLCECAGG | LECACPALLE | YARTCAQEGM | VLYGWTDHSA | CSPVCPAGME |
350:
YRQCVSPCAR | TCQSLHINEM | CQERCVDGCS | CPEGQLLDEG | LCVESTECPC |
400:
VHSGKRYPPG | TSLSRDCNTC | ICRNSQWICS | NEECPGECLV | TGQSHFKSFD |
450:
NRYFTFSGIC | QYLLARDCQD | HSFSIVIETV | QCADDRDAVC | TRSVTVRLPG |
500:
LHNSLVKLKH | GAGVAMDGQD | VQLPLLKGDL | RIQHTVTASV | RLSYGEDLQM |
550:
DWDGRGRLLV | KLSPVYAGKT | CGLCGNYNGN | QGDDFLTPSG | LAEPRVEDFG |
600:
NAWKLHGDCQ | DLQKQHSDPC | ALNPRMTRFS | EEACAVLTSP | TFEACHRAVS |
650:
PLPYLRNCRY | DVCSCSDGRE | CLCGALASYA | AACAGRGVRV | AWREPGRCEL |
700:
NCPKGQVYLQ | CGTPCNLTCR | SLSYPDEECN | EACLEGCFCP | PGLYMDERGD |
750:
CVPKAQCPCY | YDGEIFQPED | IFSDHHTMCY | CEDGFMHCTM | SGVPGSLLPD |
800:
AVLSSPLSHR | SKRSLSCRPP | MVKLVCPADN | LRAEGLECTK | TCQNYDLECM |
850:
SMGCVSGCLC | PPGMVRHENR | CVALERCPCF | HQGKEYAPGE | TVKIGCNTCV |
900:
CQDRKWNCTD | HVCDATCSTI | GMAHYLTFDG | LKYLFPGECQ | YVLVQDYCGS |
950:
NPGTFRILVG | NKGCSHPSVK | CKKRVTILVE | GGEIELFDGE | VNVKRPMKDE |
1000:
THFEVVESGR | YIILLLGKAL | SVVWDRHLSI | SVVLKQTYQE | KVCGLCGNFD |
1050:
GIQNNDLTSS | NLQVEEDPVD | FGNSWKVSSQ | CADTRKVPLD | SSPATCHNNI |
1100:
MKQTMVDSSC | RILTSDVFQD | CNKLVDPEPY | LDVCIYDTCS | CESIGDCACF |
1150:
CDTIAAYAHV | CAQHGKVVTW | RTATLCPQSC | EERNLRENGY | ECEWRYNSCA |
1200:
PACQVTCQHP | EPLACPVQCV | EGCHAHCPPG | KILDELLQTC | VDPEDCPVCE |
1250:
VAGRRFASGK | KVTLNPSDPE | HCQICHCDVV | NLTCEACQEP | GGLVVPPTDA |
1300:
PVSPTTLYVE | DISEPPLHDF | YCSRLLDLVF | LLDGSSRLSE | AEFEVLKAFV |
1350:
VDMMERLRIS | QKWVRVAVVE | YHDGSHAYIG | LKDRKRPSEL | RRIASQVKYA |
1400:
GSQVASTSEV | LKYTLFQIFS | KIDRPEASRI | TLLLMASQEP | QRMSRNFVRY |
1450:
VQGLKKKKVI | VIPVGIGPHA | NLKQIRLIEK | QAPENKAFVL | SSVDELEQQR |
1500:
DEIVSYLCDL | APEAPPPTLP | PDMAQVTVGP | GLLGVSTLGP | KRNSMVLDVA |
1550:
FVLEGSDKIG | EADFNRSKEF | MEEVIQRMDV | GQDSIHVTVL | QYSYMVTVEY |
1600:
PFSEAQSKGD | ILQRVREIRY | QGGNRTNTGL | ALRYLSDHSF | LVSQGDREQA |
1650:
PNLVYMVTGN | PASDEIKRLP | GDIQVVPIGV | GPNANVQELE | RIGWPNAPIL |
1700:
IQDFETLPRE | APDLVLQRCC | SGEGLQIPTL | SPAPDCSQPL | DVILLLDGSS |
1750:
SFPASYFDEM | KSFAKAFISK | ANIGPRLTQV | SVLQYGSITT | IDVPWNVVPE |
1800:
KAHLLSLVDV | MQREGGPSQI | GDALGFAVRY | LTSEMHGARP | GASKAVVILV |
1850:
TDVSVDSVDA | AADAARSNRV | TVFPIGIGDR | YDAAQLRILA | GPAGDSNVVK |
1900:
LQRIEDLPTM | VTLGNSFLHK | LCSGFVRICM | DEDGNEKRPG | DVWTLPDQCH |
1950:
TVTCQPDGQT | LLKSHRVNCD | RGLRPSCPNS | QSPVKVEETC | GCRWTCPCVC |
2000:
TGSSTRHIVT | FDGQNFKLTG | SCSYVLFQNK | EQDLEVILHN | GACSPGARQG |
2050:
CMKSIEVKHS | ALSVELHSDM | EVTVNGRLVS | VPYVGGNMEV | NVYGAIMHEV |
2100:
RFNHLGHIFT | FTPQNNEFQL | QLSPKTFASK | TYGLCGICDE | NGANDFMLRD |
2150:
GTVTTDWKTL | VQEWTVQRPG | QTCQPILEEQ | CLVPDSSHCQ | VLLLPLFAEC |
2200:
HKVLAPATFY | AICQQDSCHQ | EQVCEVIASY | AHLCRTNGVC | VDWRTPDFCA |
2250:
MSCPPSLVYN | HCEHGCPRHC | DGNVSSCGDH | PSEGCFCPPD | KVMLEGSCVP |
2300:
EEACTQCIGE | DGVQHQFLEA | WVPDHQPCQI | CTCLSGRKVN | CTTQPCPTAK |
2350:
APTCGLCEVA | RLRQNADQCC | PEYECVCDPV | SCDLPPVPHC | ERGLQPTLTN |
2400:
PGECRPNFTC | ACRKEECKRV | SPPSCPPHRL | PTLRKTQCCD | EYECACNCVN |
2450:
STVSCPLGYL | ASTATNDCGC | TTTTCLPDKV | CVHRSTIYPV | GQFWEEGCDV |
2500:
CTCTDMEDAV | MGLRVAQCSQ | KPCEDSCRSG | FTYVLHEGEC | CGRCLPSACE |
2550:
VVTGSPRGDS | QSSWKSVGSQ | WASPENPCLI | NECVRVKEEV | FIQQRNVSCP |
2600:
QLEVPVCPSG | FQLSCKTSAC | CPSCRCERME | ACMLNGTVIG | PGKTVMIDVC |
2650:
TTCRCMVQVG | VISGFKLECR | KTTCNPCPLG | YKEENNTGEC | CGRCLPTACT |
2700:
IQLRGGQIMT | LKRDETLQDG | CDTHFCKVNE | RGEYFWEKRV | TGCPPFDEHK |
2750:
CLAEGGKIMK | IPGTCCDTCE | EPECNDITAR | LQYVKVGSCK | SEVEVDIHYC |
2800:
QGKCASKAMY | SIDINDVQDQ | CSCCSPTRTE | PMQVALHCTN | GSVVYHEVLN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Pig
Dog
Bovine
Polyclonal Antibody for Human vWF
Polyclonal Antibody for Human vWF
Polyclonal Antibody for Human vWF
Polyclonal Antibody for Human vWF
Polyclonal Antibody for Human vWF
Polyclonal Antibody for Human vWF
Monoclonal Antibody for Human vWF
Monoclonal Antibody for Human vWF
Monoclonal Antibody for Human vWF
Monoclonal Antibody for Human vWF
Monoclonal Antibody for Human vWF
Monoclonal Antibody for Human vWF
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-852; ALA-1381 AND HIS-1472
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-471; ARG-852; ALA-1381 AND HIS-1472
3.
"The finished DNA sequence of human chromosome 12."
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Yoon L.
,
Yoon V.
,
Zorrilla S.E.
,
Nelson D.
,
Kucherlapati R.
,
Weinstock G.
,
Gibbs R.A.
more...
Nature440:346-351(2006)
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PubMed ]
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Europe PMC ]
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Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
,
Istrail S.
,
Sutton G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Lung .
6.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-1400 (ISOFORM 1);VARIANTS ARG-484; ARG-852 AND ALA-1381
7.
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Cited for : ERRATUM
8.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-178
9.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-120 (ISOFORM 1);PROTEIN SEQUENCE OF 23-56
tissue :
Umbilical vein endothelial cell .
10.
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Cited for : PROTEIN SEQUENCE OF 764-2813;VARIANTS ARG-852 AND ALA-1381
11.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 744-873 AND 1289-2813 (ISOFORM 1);VARIANTS ALA-789; ARG-852 AND ALA-1381
12.
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Cited for : PROTEIN SEQUENCE OF 764-782
tissue :
Platelet .
13.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 781-1424 (ISOFORM 1);VARIANTS ARG-852 AND ALA-1381
14.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 990-1947;VARIANTS ALA-1381 AND HIS-1472
15.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1236-1476 (ISOFORM 1);VARIANT ALA-1381
16.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2621-2813 (ISOFORM 1)
17.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2731-2813 (ISOFORM 1)
18.
Lynch D.C.
Submitted (1991-07) to the EMBL/GenBank/DDBJ databases
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Cited for : SEQUENCE REVISION
19.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2731-2813 (ISOFORM 1)
20.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2731-2813
21.
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Cited for : SUBUNIT;SUBCELLULAR LOCATION
22.
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Cited for : DISULFIDE BONDS
23.
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Cited for : STRUCTURE OF CARBOHYDRATES
24.
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Cited for : INTERACTION WITH F8
25.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1515
tissue :
Plasma .
26.
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Cited for : UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1720
tissue :
Mammary cancer .
27.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2546
tissue :
Liver .
28.
"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W.
,
Lu Z.
,
Fu Y.
,
Wang H.P.
,
Wang L.H.
,
Chi H.
,
Yuan Z.F.
,
Zheng Z.B.
,
Song L.N.
,
Han H.H.
,
Liang Y.M.
,
Wang J.L.
,
Cai Y.
,
Zhang Y.K.
,
Deng Y.L.
,
Ying W.T.
,
He S.M.
,
Qian X.H.
Mol. Cell. Proteomics8:913-923(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : GLYCOSYLATION AT ASN-1515
29.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1261-1468
30.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1685-1873
31.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1686-1872
32.
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Cited for : REVIEW
33.
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Cited for : VARIANTS VWD2 TRP-1597 AND ASP-1607
34.
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Cited for : VARIANT VWD2 THR-1628
35.
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Cited for : VARIANTS VWD2 TRP-816 AND GLN-854
36.
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Cited for : VARIANT VWD2 CYS-1308
37.
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Cited for : VARIANTS VWD2 TRP-1306; CYS-1308 AND PRO-1613
38.
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Cited for : VARIANTS VWD2 TRP-1306; CYS-1308; MET-1316 AND GLN-1341;VARIANT HIS-1399
39.
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Cited for : VARIANT VWD2 CYS-1313
40.
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Cited for : VARIANT VWD2 MET-791
41.
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Cited for : VARIANT VWD2 MET-1316
42.
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Cited for : VARIANTS VWD2 TRP-1306; MET-1316; THR-1628 AND SER-1648
43.
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Cited for : VARIANTS VWD2 TRP-1306; CYS-1308; LEU-1314 AND LEU-1318
44.
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Cited for : VARIANT VWD2 ARG-1272
45.
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Cited for : VARIANT VWD2 LYS-1638
46.
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Cited for : VARIANT VWD2 SER-1324
47.
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Cited for : VARIANTS VWD2 GLN-1597; ARG-1609 AND GLU-1665
48.
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Cited for : VARIANT VWD2 CYS-1514
49.
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Cited for : VARIANTS VWD2 GLY-1597 AND ARG-1609;VARIANT CYS-1584
50.
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Cited for : VARIANT VWD2 ASP-1268
51.
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Cited for : VARIANT VWD2 LEU-1266
52.
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Cited for : VARIANT VWD2 VAL-1460
53.
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Cited for : VARIANTS VWD2 PRO-1540 AND THR-1628
54.
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Cited for : VARIANT VWD3 TYR-2739
55.
"Genetic heterogeneity of severe von Willebrand disease type III in the German population."
Schneppenheim R.
,
Krey S.
,
Bergmann F.
,
Bock D.
,
Budde U.
,
Lange M.
,
Linde R.
,
Mittler U.
,
Meili E.
,
Mertes G.
,
Olek K.
,
Plendl H.
,
Simeoni E.
Hum. Genet.94:640-652(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT VWD3 CYS-377
56.
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Cited for : VARIANT VWD2 SER-528
57.
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Cited for : VARIANTS VWD2 CYS-1374 AND HIS-1374
58.
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Cited for : VARIANT VWD2 HIS-1374
59.
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Cited for : VARIANT VWD2 VAL-1461
60.
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Cited for : VARIANT VWD2 ARG-550
61.
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Cited for : VARIANT VWD2 ARG-2773
62.
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Cited for : VARIANT VWD1 TRP-273;VARIANT VWD3 TRP-273
63.
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Cited for : VARIANT VWD1 ARG-1149;MUTAGENESIS OF CYS-1149 AND CYS-1169
64.
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Cited for : VARIANT VWD2 ARG-1060
65.
"The prevalence of the cysteine1584 variant of von Willebrand factor is increased in type 1 von Willebrand disease: co-segregation with increased susceptibility to ADAMTS13 proteolysis but not clinical phenotype."
Bowen D.J.
,
Collins P.W.
,
Lester W.
,
Cumming A.M.
,
Keeney S.
,
Grundy P.
,
Enayat S.M.
,
Bolton-Maggs P.H.
,
Keeling D.M.
,
Khair K.
,
Tait R.C.
,
Wilde J.T.
,
Pasi K.J.
,
Hill F.G.
Br. J. Haematol.128:830-836(2005)
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PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT CYS-1584
66.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] CYS-1570
67.
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Cited for : VARIANT VWD2 PHE-1272