Protein name:
Wiskott-Aldrich syndrome protein homolog (WASp) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Binds to CDC42, RAC, NCK, FYN, SRC kinase FGR, BTK, ABL, PSTPIP1, WIP, and to the p85 subunit of PLC-gamma. Binds the Arp2/3 complex. Interacts (via C-terminus) with ALDOA.
Function:
Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.
Subcellular Location:
Cytoplasm
cytoskeleton
Protein Attributes:
50:
MNSGPGPVGG | RPGGRGGPAV | QQNIPSNLLQ | DHENQRLFEL | LGRKCWTLAT |
100:
TVVQLYLALP | PGAEHWTMEH | CGAVCFVKDN | PQKSYFIRLY | GLQAGRLLWE |
150:
QELYSQLVYL | TPTPFFHTFA | GDDCQVGLNF | ADESEAQAFR | ALVQEKIQKR |
200:
NQRQSGERRQ | LPPPPAPINE | ERRGGLPPVP | PHPGGDHGGP | SGGPLSLGLV |
250:
TVDIQNPDIT | SSRYRGLPAP | GPGPTDKKRS | GKKKISKADI | GAPSGFKHVS |
300:
HVGWDPQNGF | DVNNLDPDLR | SLFSRAGISE | AQLTDAETSK | LIYDFIEDQG |
350:
GLEAVRQEMR | RQEPLPPPPP | PCRGGGGGGG | GGGGGGGGGG | GQPLRPPVVG |
400:
SNKGRSGPLP | PVPMGGAPPP | PTPRGPPPPG | RGGPPPPPPP | ATGRSGPPPP |
450:
PLPGAGGPPA | PPPPPPPPPP | PPCPGSGPAP | PPLPPTPVSG | GSPAPGGGRG |
500:
ALLDQIRQGI | QLNKTPGALE | NSVQQPPAQQ | SEGLVGALMH | VMQKRSRVIH |
520:
SSDEGEDQTG | EDEEDDEWDD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Polyclonal Antibody for Mouse WASp
Polyclonal Antibody for Mouse WASp
Monoclonal Antibody for Mouse WASp
Monoclonal Antibody for Mouse WASp
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
2.
"Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling."
Quilliam L.A.
,
Lambert Q.T.
,
Mickelson-Young L.A.
,
Westwick J.K.
,
Sparks A.B.
,
Kay B.K.
,
Jenkins N.A.
,
Gilbert D.J.
,
Copeland N.G.
,
Der C.J.
J. Biol. Chem.271:28772-28776(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NCK1
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PSTPIP1
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-293;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Mast cell .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-293; SER-501 AND SER-502;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]