WDR48 ELISA Kit for Human(Homo sapiens) | EIAab.comWDR48 ELISA Kit for Human(Homo sapiens) | EIAab.com

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WDR48 (Gene name),

WD repeat-containing protein 48 (Protein name ), WDR48_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

WDR48(KIAA1449;UAF1);

Protein name:

WD repeat-containing protein 48;

Alternative:

WD repeat endosomal protein;USP1-associated factor 1;p80;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with USP1, USP12 and USP46. Interacts with Saimiriine herpesvirus TIP protein. Interacts with papillomavirus HPV11 E1 protein.

Function:

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

Subcellular Location:

Nucleus Cytoplasm Lysosome Mainly cytoplasmic. In case of infection by papillomavirus HPV11, translocates to the nucleus via its interaction with papillomavirus HPV11.

Protein Attributes:

Sequence length:

677

Sequence:

50:

MAAHHRQNTA | GRRKVQVSYV | IRDEVEKYNR | NGVNALQLDP | ALNRLFTAGR |

100:

DSIIRIWSVN | QHKQDPYIAS | MEHHTDWVND | IVLCCNGKTL | ISASSDTTVK |

150:

VWNAHKGFCM | STLRTHKDYV | KALAYAKDKE | LVASAGLDRQ | IFLWDVNTLT |

200:

ALTASNNTVT | TSSLSGNKDS | IYSLAMNQLG | TIIVSGSTEK | VLRVWDPRTC |

250:

AKLMKLKGHT | DNVKALLLNR | DGTQCLSGSS | DGTIRLWSLG | QQRCIATYRV |

300:

HDEGVWALQV | NDAFTHVYSG | GRDRKIYCTD | LRNPDIRVLI | CEEKAPVLKM |

350:

ELDRSADPPP | AIWVATTKST | VNKWTLKGIH | NFRASGDYDN | DCTNPITPLC |

400:

TQPDQVIKGG | ASIIQCHILN | DKRHILTKDT | NNNVAYWDVL | KACKVEDLGK |

450:

VDFEDEIKKR | FKMVYVPNWF | SVDLKTGMLT | ITLDESDCFA | AWVSAKDAGF |

500:

SSPDGSDPKL | NLGGLLLQAL | LEYWPRTHVN | PMDEEENEVN | HVNGEQENRV |

550:

QKGNGYFQVP | PHTPVIFGEA | GGRTLFRLLC | RDSGGETESM | LLNETVPQWV |

600:

IDITVDKNMP | KFNKIPFYLQ | PHASSGAKTL | KKDRLSASDM | LQVRKVMEHV |

650:

YEKIINLDNE | SQTTSSSNNE | KPGEQEKEED | IAVLAEEKIE | LLCQDQVLDP |

677:

NMDLRTVKHF | IWKSGGDLTL | HYRQKST

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

UniGene:

String:

MIM:

Pfam:

KEGG:

Uniprot:

FOR

ELISA Kit for Human WD repeat-containing protein 48

ELISA Kit for Human WD repeat-containing protein 48

ELISA Kit for Human WD repeat-containing protein 48

ELISA Kit for Human WD repeat-containing protein 48

CLIA Kit for Human WD repeat-containing protein 48

CLIA Kit for Human WD repeat-containing protein 48

CLIA Kit for Human WD repeat-containing protein 48

CLIA Kit for Human WD repeat-containing protein 48

Polyclonal Antibody for Human WD repeat-containing protein 48

Polyclonal Antibody for Human WD repeat-containing protein 48

Polyclonal Antibody for Human WD repeat-containing protein 48

Polyclonal Antibody for Human WD repeat-containing protein 48

Monoclonal Antibody for Human WD repeat-containing protein 48

Monoclonal Antibody for Human WD repeat-containing protein 48

Monoclonal Antibody for Human WD repeat-containing protein 48

Monoclonal Antibody for Human WD repeat-containing protein 48

Protein for Human WD repeat-containing protein 48

Protein for Human WD repeat-containing protein 48

Protein for Human WD repeat-containing protein 48

Protein for Human WD repeat-containing protein 48

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression."
Park J. , Lee B.-S. , Choi J.-K. , Means R.E. , Choe J. , Jung J.U.
Immunity17:221-233(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH TIP
2.

"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
DNA Res.7:143-150(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
3.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5)
tissue: Brain.
tissue: Teratocarcinoma.
tissue: Testis.
5.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-677 (ISOFORM 1)
tissue: Melanoma.
tissue: Retina.
tissue: Stomach.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
tissue: Eye.
7.

"Distinct roles of cellular Lck and p80 proteins in herpesvirus saimiri Tip function on lipid rafts."
Park J. , Cho N.-H. , Choi J.-K. , Feng P. , Choe J. , Jung J.U.
J. Virol.77:9041-9051(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HERPESVIRUS SAIMIRI TIP
8.

"A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway."
Cohn M.A. , Kowal P. , Yang K. , Haas W. , Huang T.T. , Gygi S.P. , D'Andrea A.D.
Mol. Cell28:786-797(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH USP1
9.

"Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes."
Cote-Martin A. , Moody C. , Fradet-Turcotte A. , D'Abramo C.M. , Lehoux M. , Joubert S. , Poirier G.G. , Coulombe B. , Laimins L.A. , Archambault J.
J. Virol.82:1271-1283(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH HPV11 E1
10.

"UAF1 is a subunit of multiple deubiquitinating enzyme complexes."
Cohn M.A. , Kee Y. , Haas W. , Gygi S.P. , D'Andrea A.D.
J. Biol. Chem.284:5343-5351(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH USP12 AND USP46
11.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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