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Index > Protein center > WWP2(Gene name) > Human
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  • WWP2 (Gene name),
  • NEDD4-like E3 ubiquitin-protein ligase WWP2 (Protein name ),  WWP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    WWP2;
    Protein name:
    NEDD4-like E3 ubiquitin-protein ligase WWP2;
    Alternative:
    WW domain-containing protein 2;Atrophin-1-interacting protein 2(AIP2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with POU5F1, RBP1, EGR2 and SLC11A2 (By similarity). Interacts with SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, ATN1 and adenovirus type 2 PIII. Interacts with ERBB4, NDFIP1 AND NDFIP2.
    Function:
    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    870
    Sequence:
    50:
    MASASSSRAG | VALPFEKSQL | TLKVVSAKPK | VHNRQPRINS | YVEVAVDGLP | 
    100:
    SETKKTGKRI | GSSELLWNEI | IILNVTAQSH | LDLKVWSCHT | LRNELLGTAS | 
    150:
    VNLSNVLKNN | GGKMENMQLT | LNLQTENKGS | VVSGGELTIF | LDGPTVDLGN | 
    200:
    VPNGSALTDG | SQLPSRDSSG | TAVAPENRHQ | PPSTNCFGGR | SRTHRHSGAS | 
    250:
    ARTTPATGEQ | SPGARSRHRQ | PVKNSGHSGL | ANGTVNDEPT | TATDPEEPSV | 
    300:
    VGVTSPPAAP | LSVTPNPNTT | SLPAPATPAE | GEEPSTSGTQ | QLPAAAQAPD | 
    350:
    ALPAGWEQRE | LPNGRVYYVD | HNTKTTTWER | PLPPGWEKRT | DPRGRFYYVD | 
    400:
    HNTRTTTWQR | PTAEYVRNYE | QWQSQRNQLQ | GAMQHFSQRF | LYQSSSASTD | 
    450:
    HDPLGPLPPG | WEKRQDNGRV | YYVNHNTRTT | QWEDPRTQGM | IQEPALPPGW | 
    500:
    EMKYTSEGVR | YFVDHNTRTT | TFKDPRPGFE | SGTKQGSPGA | YDRSFRWKYH | 
    550:
    QFRFLCHSNA | LPSHVKISVS | RQTLFEDSFQ | QIMNMKPYDL | RRRLYIIMRG | 
    600:
    EEGLDYGGIA | REWFFLLSHE | VLNPMYCLFE | YAGKNNYCLQ | INPASSINPD | 
    650:
    HLTYFRFIGR | FIAMALYHGK | FIDTGFTLPF | YKRMLNKRPT | LKDLESIDPE | 
    700:
    FYNSIVWIKE | NNLEECGLEL | YFIQDMEILG | KVTTHELKEG | GESIRVTEEN | 
    750:
    KEEYIMLLTD | WRFTRGVEEQ | TKAFLDGFNE | VAPLEWLRYF | DEKELELMLC | 
    800:
    GMQEIDMSDW | QKSTIYRHYT | KNSKQIQWFW | QVVKEMDNEK | RIRLLQFVTG | 
    850:
    TCRLPVGGFA | ELIGSNGPQK | FCIDKVGKET | WLPRSHTCFN | RLDLPPYKSY | 
    870:
    EQLREKLLYA | IEETEGFGQE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    MIM:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human NEDD4-like E3 ubiquitin-protein ligase WWP2
    ELISA Kit for Human NEDD4-like E3 ubiquitin-protein ligase WWP2
    CLIA Kit for Human NEDD4-like E3 ubiquitin-protein ligase WWP2
    CLIA Kit for Human NEDD4-like E3 ubiquitin-protein ligase WWP2
    Polyclonal Antibody for Human NEDD4-like E3 ubiquitin-protein ligase WWP2
    Polyclonal Antibody for Human NEDD4-like E3 ubiquitin-protein ligase WWP2
    Monoclonal Antibody for Human NEDD4-like E3 ubiquitin-protein ligase WWP2
    Monoclonal Antibody for Human NEDD4-like E3 ubiquitin-protein ligase WWP2
    Protein for Human NEDD4-like E3 ubiquitin-protein ligase WWP2
    Protein for Human NEDD4-like E3 ubiquitin-protein ligase WWP2

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Identification of novel human WW domain-containing proteins by cloning of ligand targets."
      Pirozzi G. , McConnell S.J. , Uveges A.J. , Carter J.M. , Sparks A.B. , Kay B.K. , Fowlkes D.M.
      J. Biol. Chem.272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH WBP1; WBP2; SCNN1A; SCNN1B AND SCNN1G
      tissue: Bone marrow.
      tissue: Brain.
    2. 2.
      "Bioinformatic analysis of E3 ligase WWP2 in 14 different vertebrates."
      Jiang G.Y. , Yang J.H. , Liu S.F.
      Submitted (2011-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Placenta.
      tissue: Testis.
      tissue: Trachea.
    4. 4.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
      tissue: Brain.
      tissue: Ovary.
      tissue: Placenta.
    7. 7.
      "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins."
      Wood J.D. , Yuan J. , Margolis R.L. , Colomer V. , Duan K. , Kushi J. , Kaminsky Z. , Kleiderlein J.J. Jr. , Sharp A.H. , Ross C.A.
      Mol. Cell. Neurosci.11:149-160(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATN1;TISSUE SPECIFICITY
    8. 8.
      "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel."
      McDonald F.J. , Western A.H. , McNeil J.D. , Thomas B.C. , Olson D.R. , Snyder P.M.
      Am. J. Physiol.283:F431-F436(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCNN1A; SCNN1B AND SCNN1G
    9. 9.
      "Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases."
      Galinier R. , Gout E. , Lortat-Jacob H. , Wood J. , Chroboczek J.
      Biochemistry41:14299-14305(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADENOVIRUS TYPE 2 PIII
    10. 10.
      "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein."
      Harvey K.F. , Shearwin-Whyatt L.M. , Fotia A. , Parton R.G. , Kumar S.
      J. Biol. Chem.277:9307-9317(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NDFIP1
    11. 11.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain."
      Wiesner S. , Ogunjimi A.A. , Wang H.R. , Rotin D. , Sicheri F. , Wrana J.L. , Forman-Kay J.D.
      Cell130:651-662(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOINHIBITION BY C2 DOMAIN
    13. 13.
      "WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells."
      Xu H. , Wang W. , Li C. , Yu H. , Yang A. , Wang B. , Jin Y.
      Cell Res.19:561-573(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF POU5F1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INTERACTION WITH POU5F1;MUTAGENESIS OF CYS-838
    14. 14.
      "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins."
      Mund T. , Pelham H.R.
      EMBO Rep.10:501-507(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVATION BY NDFIP1 AND NDFIP2;AUTOUBIQUITINATION
    15. 15.
      "The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination."
      Chen A. , Gao B. , Zhang J. , McEwen T. , Ye S.Q. , Zhang D. , Fang D.
      Mol. Cell. Biol.29:5348-5356(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF EGR2;INTERACTION WITH EGR2
    16. 16.
      "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."
      Gilmore-Hebert M. , Ramabhadran R. , Stern D.F.
      Mol. Cancer Res.8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH ERBB4;SUBCELLULAR LOCATION
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1."
      Cui Y. , He S. , Xing C. , Lu K. , Wang J. , Xing G. , Meng A. , Jia S. , He F. , Zhang L.
      EMBO J.30:2675-2689(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;MUTAGENESIS OF LYS-498 AND HIS-500
    19. 19.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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