Professor Michael n. Hall of the university of Basel, Switzerland, and his team have discovered a new cancer-fighting protein, LHPP, that prevents uncontrolled proliferation of hepatocellular carcinoma cells.They reported that LHPP could also be a biomarker for diagnosis and prognosis of liver cancer.The results of the study were published in the journal Nature on March 21, 2018. The study was titled "protein histidine phosphatase LHPP is a tumor suppressor".
Liver tumors are produced by mutant cells that grow and are not controlled.Cancer-fighting proteins, known as tumor suppressor proteins, prevent uncontrolled cell growth.Now, the hall's team has discovered a new tumor suppressor proteins LHPP, their research confirmed that the loss of LHPP promoted the growth of tumor and reduce the survival of cancer patients, LHPP may as a prognostic biomarker.
By activating the mTOR signal in the liver, the researchers developed a mouse liver cancer model.They analyzed more than 4,000 proteins and compared them with healthy tissue and tumor tissue.One of the most popular enzymes is histidine phosphatase LHPP.LHPP exists in healthy tissue and does not exist in tumor tissues.The researchers reintroduced genetic information encoded by LHPP to prevent tumor formation and maintenance of liver function.Similar to the mouse model, researchers like Hindupur also observed a significant decrease in LHPP levels in liver cancer patients, and the severity and life expectancy of the disease were related to LHPP level.Due to the lack of this tumor suppressor protein, cancer patients died on average two years ago.LHPP is a biomarker for tumor classification.As a phosphatase, LHPP removes phosphate groups that bind to histidine proteins.Like all amino acids, histidine is an essential component of protein.Due to the lack of LHPP, global protein histidine phosphorylation increases, which may lead to the activation of some important functions and uncontrolled cell proliferation.This defect promotes tumor growth by increasing the production of histidine phosphorylated protein.Tumor suppressor protein LHPP may also play a role in the development of other cancers.
EIAAB SCIENCE INC, WUHAN has LHPP related kit for sale, welcome to consult and choose.
