The study found that metastatic cancer cells can leave tumors and spread in large groups, rather than acting alone. Scientists from the University of California studied the key processes this behavior helps. When a cancer metastasizes, the host cell (the front end) expends more energy and blocks the cell from moving forward, creating a new tumor site.
The research is important for advancing the field of metabolomics, which is a new field in the fight against cancer. Researchers using metabolomics to slow down the production of cancer cells may shed light on the molecular mechanisms involved in cancer cell metastasis.
In this study, the researchers said, they found that in addition to proliferation, cancer cells also require energy to migrate, which means that scientists can use cancer cells' metabolism to guide their migration. The researchers used lung cancer cells to study and further elucidate the mechanisms by which these cancer cells metastasize, which is crucial to the development of new anticancer therapies.
Researchers study of lung cancer cells, they have developed a new way of computing simulation, confirmed the front and rear cancer cells in the process of cancer metastasis are energy demand, and front cells need to be as much as 60% of energy, mainly due to the density of the through the organization, and metastasis of cancer cells every 5 hours will convert a cell role to promote effective cancer metastasis.
The researchers say the development of fluorescent biosensors could help track energy-releasing molecules in cancer cells. They will also conduct further research to elucidate new molecular mechanisms of cancer cell metastasis and develop new therapies to inhibit cancer metastasis.