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Photoperiod-Dependent Effects of 4-tert-Octylphenol on Adherens and Gap Junction Proteins in Bank Vole Seminiferous Tubules
Update time:2013-07-30 00:11:09   【 Font: Large  Medium Small

Abstract

In the present study we evaluated in vivo and in vitro efects of 4-tert-octylphenol (OP) on the expression and distribution of adherens and gap junction proteins, N-cadherin, β-catenin, and connexin 43 (Cx43), in testes of seasonally breeding rodents,bank voles. We found that in bank vole testes expression and distribution of N-cadherin, β-catenin, and Cx43 were photoperiod dependent. Long-term treatment with OP (200mg/kg b.w.) resulted in the reduction of junction proteins expressions (P < 0.05,P < 0.01) and their delocalization in the testes of males kept in long photoperiod, whereas in short-day animals slight increase of Cx43 (P < 0.05), N-cadherin, and β-catenin (statistically nonsigniicant) levels was observed. Efects of OP appeared to be
independent of FSH and were maintained during in vitro organ culture, indicating that OP acts directly on adherens and gap junction proteins in the testes. An experiment performed using an antiestrogen ICI 182,780 demonstrated that the biological efects of OP on β-catenin and Cx43 involve an estrogen receptor-mediated response. Taken together, in bank vole organization of adherens and gap junctions and their susceptibility to OP are related to the length of photoperiod. Alterations in cadherin/catenin and Cx43-based junction may partially result from activation of estrogen receptor α and/or β signaling pathway.

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Source:International Journal of Endocrinology      by Anna Hejmej,Malgorzata Kotula-Balak, Katarzyna Chojnacka, Paulina Kuras,Marta Lydka-Zarzycka, and Barbara Bilinska
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