Language:
  
[Sign in] [Register]   

EIAab logo

EIAab news detail, please contact eiaab@eiaab.com if you have any questions about online orders and payment.
Serum betatrophin level increased in subjects with nonalcoholic fatty liver disease
Update time:2016-08-01 22:50:57   【 Font: Large  Medium Small

Abstract

Background: Betatrophin is a novel adipokine/hepatokine that promotes pancreatic β-cell proliferation and regulates lipid metabolism.

Aims: This study is to evaluate the role of serum betatrophin in nonalcoholic fatty liver disease (NAFLD).

Methods: A hospital-based age-/gender-/Body Mass Index-matched case-control study of 194 subjects was conducted in Hangzhou, China. Serum level of Betatrophin was measured and validated by enzymelinked immunosorbent assay and western blotting. The serum levels of 12 adipokines were evaluated by commercial Adipokine Magnetic Bead Panel kits. Statistical analyses included receiver operating characteristic (ROC) curve, bivariate correlation, and multivariate stepwise linear regression.

Results: Serum Betatrophin witnessed a higher level in NAFLD patients (1094.98 ± 541.31 pg/mL, P < 0.001), compared with controls (730.03 ± 431.10 pg/mL). Compared with the lowest tertile of serum Betatrophin level, the highest tertile indicated an association with higher odds of NAFLD (adjusted Odds Ratio = 2.012, 95% Confidence interval [CI] [1.285-3.148], P = 0.002). ROC curve of Betatrophin was developed to predict the presence of NAFLD (Area under ROC = 0.702 [95% CI 0.628-0.777t, P < 0.001). Furthermore, Betatrophin correlated with several parameters, including age, Waist-to-hip ratio, Fasting plasma glucose, Haemoglobin A1C, Homeostasis model assessment of insulin resistance, and Fasting C Peptide, and various adipokines, including Resistin, Interleukin-8, and tumor necrosis factor-α.

Conclusions: Serum Betatrophin level increased in subjects with NAFLD and was associate with parameters of β-cell function and inflammation

 

Cited products
Source:Int J Clin Exp Med      by Zhu J, Li C, Dai Y, et al.
Hot Genes
ALCAM ACE KSR2 ASPRO C19orf80 Gdf5 Trap1a Atf2
Top Searches
Ubiquitin ELISA Ubiquitin-protein ligase metalloproteinase Asprosin TRAP1A Tumor necrosis vitamin d
Why choose EIAAB
Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
Further Information
About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

Twitter