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Beta-defensin 1

Posted by star on 2016-08-29 22:58:35
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Defensins comprise a subclass of small, cysteine-rich, cationic antimicrobial peptides produced by higher organisms. Mammalian defensins are further classified into α-defensins and β-defensins based on both precursor and gene structure, as well as a pattern of six cysteines forming three disulfide bones and an overall length of 25-45 amino acids. The β-Defensins are mainly activated against Gram-negative bacteria and yeast, although many also have activity against Gran-positive bacteria.

The human β-defensin 1 (hBD1), which has 36 amino acids, was originally isolated from hemofiltrates of patients with advanced renal failure. The hBD1 gene is constitutively expressed in the genitourinary tract, respiratory tract and placental tissue, its expression is not affected by the production of in?ammatory mediators.

The hBD-1 crystal structure has been parsed (Fig. 1). The monomer of hBD1 displays a fold with a three-stranded β-sheet stabilized by three disulfide bonds, similar to that of hBD2 and bovine β-defensin 12.

 

Fig. 1 The crystal structure of human beta–defensin 1 (From reference 3)

hBD-1 was a significant factor pathophysiologically in infectious renal diseases. hBD-1 is probably the most important antimicrobial peptide in urinary and respiratory epithelial tissues. It is unique in its constitutive expression, but is still capable of up-regulation upon inflammation or microbial stimuli. It was not clear whether hBD-1 responded to infection and if this response reflects more secretion from normal epithelium or release from damaged cells.

 

Wuhan EIAab Science Co.,Ltd is advantage in technology, product, dedicated to provide quality and reliable for all users of products. Our company has developed beta-defense 1 protein of different genus ......

Superoxide Dismutase (SOD)

Posted by star on 2016-08-29 22:37:39
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Superoxide dismutase (SOD) is a kind of catalytic superoxide by disproportionation reaction which is converted into oxygen and hydrogen peroxide enzyme. It widely exists in all kinds of animals, plants, microorganisms. It is an important antioxidant, protecting cells exposed to oxygen.

SOD is found by Irwin Fridovich and Joe McCord for the first time. They were previously thought to be a few metal proteins of unknown function.  SOD exists in the several common forms: they're in, manganese, or iron, copper and zinc or nickel as a cofactor.

In the human body (similar to the most other mammals and chordata), SOD also contains three types: SOD1 positioning in the cytoplasm; SOD2 located in the mitochondria; SOD3 located outside the cell. SOD1 and SOD3 active site contains copper and zinc, whereas SOD2 containing manganese. Their genes were located in chromosome 21.

Superoxide is one of the major active oxygen in the cells, so the SOD has played a key role in antioxidants. SOD plays an important physiological role, the lack of the enzyme after genetically engineered mice suffer from serious disease. For example, lack of SOD2 mice in a few days after birth are died of severe oxidative stress; lack of SOD1 mice have a wide range of pathological characteristic, including HCC (hepatocellular carcinoma), and the quality of the muscles that related to age speed reduced, cataract occurred early and the life reduced; Lack of SOD3 mice showed no obvious flaws and have normal life, but they are more prone to high oxygen injury. Eliminate any kind of SOD of mice easier to die in the oxide production of reagents, such as paraquat and diquat. Flies lacking of SOD1 were significantly shorten the life, and the lack of SOD2 would die before birth. Elegans knockout of SOD don't lead to serious physiological disorders. The knockout or lack of SOD1 mutations in saccharomyces cerevisiae grow in anaerobic environment is very bad, and lead to second peak growth......

Neuronal Nitric Oxide Synthase (nNOS)

Posted by star on 2016-08-29 02:27:30
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Neuronal Nitric Oxide Synthase (nNOS), which is also known as  NOS1, produces NO in both the central and peripheral nervous system. The gene encoded for nNOS is located on the chromosome-12. nNOS is associated with plasma membranes and also performs a role in cell communication. nNOS action can be inhibited by NPA (N-propyl-L-arginine). This form of the enzyme is specifically inhibited by 7-nitroindazole.

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine.

In the brain and peripheral nervous system, nitric oxide displays many properties of neurotransmitter, and associates with stroke and neurodegenerative diseases, regulates of smooth muscle neural, including peristalsis, and penile erection related nerve impulse. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Moreover, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.

Wuhan EIAab Science Co., Ltd is strong in technology, product, dedicated to provide quality and reliable products for all users. The human Neuronal NOS ELISA Kit (Cat No.E0628h) is high sensitivity and specificity.



diabetes drug metformin inhibition of pancreatic cancer progress

Posted by star on 2016-08-21 23:46:39
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Recently, the Massachusetts general hospital (MGH) researchers found that "diabetes drug metformin inhibition of pancreatic cancer progress" behind this ability of a new mechanism. Metformin is a kind of double guanidine kind oral fall blood sugar medicine, particularly suited to use simple diet control and physical exercise therapy invalid type II diabetes, namely obese type 2 diabetes


The researchers first found in obese animals model of pancreatic cancer, those who take metformin, the expression of hyaluronic acid and collagen protein-1 drop, with less activation of pancreatic stellate cells (PSC).Research in artificial culture cell, identified metformin to reduce PSCs produce hyaluronic acid and collagen protein-1, and prevent tumor associated macrophage (can increase inflammatory environment) recruitment of signal transduction pathways.


Using Metformin combine with insulin, can reduce the dosage of insulin, prevent the occurrence of hypoglycaemia. Insulin, as a kind of common diabetes drug, has a large demand. EIAAB can provide accurate detection of insulin levels in biological samples related ELISA kit,  for scientific researcher to order.



EIAab will participate in BioTaiwan 2016 Exhibition

Posted by star on 2016-06-21 23:38:16
Hits:462

Jul 21st-July 24th, Wuhan EIAab Science Co.,Ltd( EIAab) will participate in BioTaiwan 2016 Exhibition. We hereby sincerely invite you and your company representatives to visit our booth at booth #N021 (Taipei world trade center-Nangang Exhibition Hall 4F).

It would be a great pleasure to meet you at the exhibition, we expect to establish long-term business relations with your company in the future. http://www.eiaab.com/

 

Join us at BioTaiwan 2016 - one of the largest biotech events in Asia
 
BioTaiwan 2016, the 14th annual biotech events is taking place this year 20-24 July in Taipei, Taiwan. One of the largest gatherings of its kind in Asia is fully packed with five events in one includes the BioBusiness Asia conference for investment, conference on Greater China Opportunities, company presentations and one-on-one partnering, seminars, workshops and BioTaiwan Exhibition with 1,260 booths from more than 670 companies. http://bio-taiwan.com/en

 



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