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Function and application of Epidermal Growth Factor

Posted by star on 2018-03-14 18:50:41

         In 1962, Cohen first discovered the epidermal growth factor (EGF), which is a small molecule polypeptide widely found in human or animal body, consisting of 53 amino acids. EGF binds to the epidermal growth factor receptor (EGFR) on the cell membrane to regulate important biological processes together, such as cell differentiation, division and proliferation. Because of the in-depth study on the structure and mechanism of EGF, Montalcini and Cohen won the 1986 Nobel Prize in Physiology and Medicine.

         A large number of studies have shown that EGF can delay the aging of the skin and restore the vitality of the epidermis, so that the skin can restore soft, elastic and normal tension, playing a role of anti-wrinkle. Besides, EGF can activate the basal cells of the skin, which can promote the healing of cutaneous and mucosal wounds, playing a role of anti-inflammatory, analgesic and preventing ulcers. In addition, EGF can also egulate the secretion of gastric acid and digestive, thereby protecting the gastrointestinal mucosa, and promoting mucosal injury repair.




        According to the good physiological characteristics of EGF, it is often used as a medicine widely in the treatment of skin burns, corneal transplants and post-operative wounds, which shows good therapeutic effects. In recent years, EGF is often added to cosmetics as a bioactive agent for sun protection, whitening, anti-aging and other effects, which greatly improves the cosmetics skin care features and the quality and grade of cosmetics.

        Due to the power of EGF, more and more researchers are interested in it. In order to meet the needs o......

Bacteriophages may help maintain human health

Posted by star on 2018-02-04 18:01:15

          Bacteriophages were found to kill bacteria in the wreckage of World War I soldiers. A century later, the virus is drawing new attention because of its potential role in the human body. From the ocean to the soil, bacteriophages are almost ubiquitous. Now, one study shows that humans absorb up to 30 billion phages each day through the gut. Although the exact location of the virus is still unknown, recent data and other studies have prompted scientists to suspect that a large number of phages in the body - the "phage group" - may influence the physiology by regulating the immune system. A study of various animals from corals to humans found that the phage abundance in the mucus layer was more than four times greater than that in the surrounding environment, as was the case for phagosomes that protect human gums and gut. As it turns out, the outer sheath of the bacteriophage binds to mucus that is secreted by the body in large quantities and mucus together with water. Attached to the mucus makes the phage to encounter more bacterial prey. As a result, it has been demonstrated in a series of in vitro studies that these viruses protect the basal cells from possible bacterial pathogens and thus provide an additional immunological layer.


A new antibody may block HIV infection

Posted by star on 2018-01-16 23:42:52

        HIV(Human Immunodeficiency Virus), is an Lentivirus that infects the human immune system and is one of the antiretroviruses. In 1983, the human immunodeficiency virus was first detected in the United States. The virus destroys the body's immune system and causes the immune system to lose its resistance, leading to diseases and cancers that can survive in the body and eventually lead to AIDS.

        In a new study, the researchers from USA have produced a kind of three specific antibody, and the three specific antibody of three HIV combined fragments derived from the three kinds of natural antibodies,  that are effective in neutralizing many HIV strains.In the lab, this three specific antibody can prevent more HIV strains from infecting cells than a single natural antibody, and it can be incorporated into three different critical sites of HIV.



          At present, the researchers are planning an early clinical trial of the three-specific antibody among healthy people and people with HIV, and hope that it will eventually be used for long-term prevention and treatment of HIV. By combining with three different sites of HIV, the virus should be more difficult to escape from the three-specific antibody than a single natural antibody. Maybe this new antibody will stop the HIV infection. Wuhan EIAab research staff have developed various research kits and welcome the selection of scientific research personnel.



High salt intake changes the gut flora in mice

Posted by star on 2018-01-07 17:27:50

         November 16, "Nature" online published a report that high salt intake will change the intestinal flora of mice. The above findings highlight the potential of gut microbiomes as potential therapeutic targets for salt-resistant diseases, given the growing acceptance of gut flora in the disease.

         High salt intake, which is linked to modern lifestyles, may lead to hypertension and cardiovascular disease. TH17 cells may also be linked to hypertension by inducing autoimmunity by proinflammatory TH17 cells.

        To determine the effect of high salt intake on gut flora, Dominik Müller and colleagues at the Max Breck Molecular Institute in Berlin, Germany, analyzed fecal samples from mice fed normal-salt and salt-fed diets. As a result, it was found that on the 14th day, there was a significant reduction in various microorganisms in mice fed high salt diet. Later, they used 16S ribosomal DNA sequencing and computational methods to identify the most important reduced flora and found that one Lactobacillus murinus was most associated with high-salt foods.

        Further studies showed that injection of Lactobacillus murinus into mice decreased TH17 cells and prevented salt-induced exacerbation of actively-induced experimental autoimmune encephalomyelitis (encephalitis mouse model) and salt-sensitive hypertension. Another small pilot study in healthy humans found that increasing salt intake reduced the survival of a wide range of Lactobacilli bacteria with an increase in TH17 cells and an increase in blood pressure, consistent with the above findings. However, further research is needed in humans.



           Tumor metabolic reprogramming and abnormal cell cycle regulation are two important characteristics of tumors. However, it is unclear how the two are coordinated to promote tumor cell proliferation and tumor development. This team found for the first time that in tumor cells, Plk1, an important cyclic regulatory protein, regulates the activity of G6PD, a key metabolic enzyme in the pentose phosphate pathway, and thus promotes the synthesis of biological macromolecules and the proliferation of tumor cells both in vitro and in vivo. Further mechanistic studies revealed that Plk1 modifies G6PD by binding and phosphorylation, resulting in an increase of G6PD-forming dimers, thereby promoting enzyme activity and the entire pentose phosphate pathway. Enhanced pentose phosphate pathway for tumor cell cycle progression and the occurrence and development of tumors have an important role in promoting. This study, for the first time, uncovered the new function of Plk1 in the regulation of biological macromolecule synthesis, revealed a new mechanism of coordination between metabolic reprogramming and cycle regulation and promotion of rapid proliferation of tumor cells, and potential therapeutic targets for clinical tumor Guiding significance.

          Wuhan EIAab Science Co., Ltd is advantage in technology, product, dedicated to provide quality and reliable for all users of products. There are some related products sold in our company related to this paper, such as Plk1(E1662h)、G6PD(E0716h) etc.





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