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Spider silk proteins help the vaccine activate immune cells

Posted by star on 2018-07-05 23:08:12

Recently, Swiss and German researchers have devised a new program for the manufacture of vaccines. The use of spider silk proteins to encapsulate antigens can safely transport antigens to T cells in lymphoid tissues, greatly enhancing the effectiveness of vaccines in stimulating immune responses. Researchers said the technology helps design a stable, easy-to-use, storage-resistant vaccine.

For cancer and some important infectious diseases, small pieces of protein, antigenic peptides, need to be delivered to T cells so that they can learn to recognize related pathogens and produce immunity. If injected directly, antigenic peptides will decompose before reaching the "destination". How to safely and efficiently transport antigenic peptides is a difficult point in the development of vaccines.

The researchers published the paper Engineered hybrid spider silk particles as delivery system for peptide vaccines in the International Journal of Biomaterials. They combined antigenic peptides with a spider silk protein to create nano-sized particles that successfully delivered antigen peptides and activated T cells without the need for a vaccine adjuvant, and showed no evidence of immunotoxicity.

The vaccine particles are very stable, easy to manufacture and can be adjusted as needed. In addition, the vaccine particles have good heat resistance and can be stored in an environment exceeding 100 degrees Celsius for several hours.

Researchers first artificially synthesize human prions

Posted by star on 2018-07-04 19:21:56

The famous mad cow disease is caused by prions. Such prion diseases not only affect animals, but also seriously endanger human health. American researchers recently published Artificial strain of human prions created in vitro in the journal Nature-Communication. They first synthesized human prions, which are important for understanding the structure and replication of the virus and developing therapeutic methods.

The essence of prions is protein. If the protein in the central nervous system of humans and some animals is folded incorrectly, it will form a prion with infectious properties. They are constantly combined with adjacent normal proteins in the brain, causing cavernous cavities in the brain, leading to symptoms such as degeneration of the brain and dementia and eventually death.

Previously, researchers were able to extract several prions from rodents, but mouse experiments have shown that these prions are not contagious to humans, and their structure and replication are different from human prions.

Researchers have used genetic technology to engineer E. coli to produce human prions, eventually resulting in a new, highly destructive human prion. The ability to synthesize human prions in test tubes will allow us to gain a deeper understanding of its structure and replication, which is critical for the development of inhibitors.

The researchers also discovered a cofactor involved in prion diseases: ganglioside GM1. It plays a regulatory role in inte......

Researchers Determine Pancreatic Cancer Tissue Consumption Mechanism

Posted by star on 2018-07-03 19:13:48

On June 21, Nature published Altered exocrine function can drive adipose wasting in early pancreatic cancer. This study shows that changes in exocrine function of the pancreas may be the cause of adipose tissue and skeletal muscle depletion in patients with pancreatic cancer.

Changes in cellular metabolism are symptoms exhibited by various cancers. Peripheral tissue depletion is particularly closely related to pancreatic cancer. This metabolic syndrome lowers the quality of life and is also thought to reduce the survival rate of cancer patients. There are many causes of organizational consumption, but it has been difficult to determine the exact underlying mechanism.

Researchers found that the loss of adipose tissue and skeletal muscle occurred early in the development of the disease through the mouse model of pancreatic cancer, and that it caused the growth of pancreatic tumors rather than tumor growth in other parts of the body. They also stated that a decline in the exocrine function of the pancreas will promote the loss of adipose tissue. Supplementation with pancreatic enzymes can reduce peripheral tissue depletion, but it will not increase the survival rate of mice.

Of the 782 pancreatic cancer patients, 65% had symptoms of skeletal muscle depletion at the time of diagnosis. However, adipose tissue and skeletal muscle depletion were not associated with reduced patient survival. Therefore, peripheral tissue depletion in the early stages of pancreatic cancer may be an early warning s......

"Key genes" that affect women ovulation and conception

Posted by star on 2018-07-02 19:40:20

Chinese scientist published Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice on PNAS. The study found that a gene called mtor plays a decisive role in whether women can discharge normal healthy ovum. According to the authors, the mtor gene can "produce" a key factor, MTOR, responsible for maintaining nutrient and stress-induced signaling pathways.

The researchers tried to knock out the mtor gene at various stages of follicular development in the female and found that the female could not excrete a healthy ovum once the MTOR pathway was inactivated which will lead to infertility.

Is there a way to prevent it? The findings may be disappointing. The author said, "Because the mtor gene has already played a decisive role before the woman was born." The authors suggest that women of childbearing age should maintain a reasonable and healthy diet and lifestyle, exercise properly and avoid overstimulation and stress to maintain the MTOR pathway in its best activity.

Wuhan EIAab Science Co., Ltd has developed several related kits such as E14969h. Welcome scientific research workers to choose and purchase.

    LIMA1 is a key protein regulating intestinal cholesterol absorption and is specifically expressed in the small intestine. A high concentration of low-density lipoprotein cholesterol (LDL-C) is a major risk factor for cardiovascular disease. LDL-C concentration is influenced by environmental and genetic factors. The genetic factors affecting LDL-C are not fully characterized.

   On June 8, 2018,Science published an article called A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. The article showed that inhibiting LIMA1 can reduce cholesterol absorption and help treat hypercholesterolemia.

   In this study, a family of low-LDL-C Kazakh ancestry was analyzed, and a special gene mutationwas successfully isolated— LIMA1 mutation. Individuals with low LDL-C levels in the blood carry the LIMA1 gene mutation.Those without the mutation had normal LDL-C levels.This mutation causes the production of the LIMA1. LIMA1-deficient mice display lower dietary cholesterol absorption.LIMA1 bridged NPC1L1, an essential protein for cholesterol absorption, to a transportation complex containing myosin Vb and facilitated cholesterol uptake.

   Wuhan EIAab Science Co., Ltd has developed LIMA1 protein, antibody and ELISA kit. Welcome scientific research workers to choose and purchase.

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