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New drug therapy restores partial hearing in deaf mice

Posted by star on 2018-09-10 00:44:03

Deafness is a genetically dominant feature of the LMG2 family, which means that a child inherits a defective copy of the gene from his parents and experiences progressive hearing loss. The mutation of the deafness is located in the region of DFNA27 on chromosome 4. This area contains more than a dozen genes. However, the precise location of this mutation has been unknown.

Most of the previous studies ignored the fourth exon in the Rest gene,because this small exon was not edited into the Rest mRNA of most cells. The normal function of REST proteins is to shut down genes that are only active in a few cell types.

On June 28, a study published Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness in Cell showed that exon 4 of mouse Rest was deleted, and ear hair cells died, resulting in a deaf mouse phenotype. The researchers found that many genes that should have been active were shut down before hair cells died. Thus, they reanalyzed the deafness mutations in the LMG2 family and found that the mutations were close to exon 4, altering the boundaries of exon 4, while the REST of hair cells was inactivated.

Integrating exon 4 into REST mRNA is equivalent to a switch that senses hair cells, which shuts down REST and opens up many gene expressions. Activation of these genes is important for hair cell survival and hearing.

Using an exon 4-deficient mouse model, the researchers found that REST inhibits gene expression primarily through a process called histone deacetylation. As a result, they used small molecule drugs that inhibited this process, down-regulating the effects of REST, and successfully restored the mice to partial hearing.

Wuhan EIAab Science Co., Ltd has developed REST protein, antibody and ELISA kit.

Welcome scientific research workers to choose and purchase.

Research Found Key Substances in the Pathogenesis of Psoriasis

Posted by star on 2018-09-06 18:53:36

    A new study in Japan found that in the pathogenesis of psoriasis, a signaling molecule in skin cells plays a key role, and on this basis, it is expected to develop new therapeutic methods.

    Psoriasis is a skin disease associated with immune abnormalities, manifested by erythema, silver shavings and itching on the skin. According to the researchers, psoriasis patients account for about 3% of the global population. In recent years, injection antibody therapy has a good effect, but the cost of treatment is high, and some patients may have antibody failure.

    In a new issue of Epithelial TRAF6 drives IL-17–mediated psoriatic inflammation on the Journal of JCI Insight, the researchers reported that a signal molecule "TRAF6" in skin cells plays a key role in the pathogenesis of psoriasis.

    In mice, mice lacking this signaling molecule do not develop psoriasis. Even when these mice were injected with immunomodulatory factors, immune abnormalities that could have caused psoriasis were induced, and psoriasis was still suppressed.

    Researchers therefore believe that new treatments for psoriasis can be developed for this signaling molecule to address the challenges of previous related therapies.

    Wuhan EIAab Science Co., Ltd has developed several related kits such as E8869h, E8869m, E0063h and E2103h etc. Welcome scientific research workers to choose and purchase.

    Recently, the Chinese research team found that phage lyase can kill bacteria that cause dental caries, but it is harmless to common oral symbiotic bacteria, and it can be confirmed by rat dental caries model to significantly reduce the degree of dental caries.

    Caries, commonly known as cavities or fangs, are oral diseases in which teeth are broken and gradually form cavities. They are the main cause of tooth loss. Oral diseases, including caries, have a great impact on our quality of life. According to the researchers, the production of dental caries is mainly caused by the long-term interaction of bacteria with food. The main caries are Streptococcus mutans and Streptococcus sobrinus.

    This study was based on the previous discovery that phage lyase has a broad spectrum of Streptococcus mutans, and further tested the killing effect on other oral fungi and common oral commensal bacteria. The results showed that phage lyase deformed common caries Streptococcus mutans and Streptococcus sobrinus and related biofilms have bactericidal effects, but have almost no killing effect on oral symbiotic bacteria such as Streptococcus sanguinis, Streptococcus oralis, and Streptococcus salivarius.

    The study found that phage lyase also kills Enterococcus faecalis that causes periapical periodontal infection and eliminates biofilm. Related research Activity of the Chimeric Lysin ClyR against Common Gram-Positive Oral Microbes and Its Anticaries Efficacy in Rat Models were recently published on Virus. This research means that phage lyase has a good prospect in the prevention and treatment of dental diseases such as dental caries, and it may provide new drugs and tooth care products for the p......

New research suggests that e-cigarette is still harmful to the lung

Posted by star on 2018-09-04 19:10:41

    E-cigarettes are used as a substitute for traditional cigarettes by many people, but the scientific community is controversial about its health risks. A new study in the UK believes that e-cigarette vapor can damage lung immune cells, and the risk of e-cigarettes may be greater than previously thought.

    In the laboratory, the researchers simulated the exposure of vapors produced by the heating of electronic cigarettes to alveolar macrophages from healthy non-smokers. Alveolar macrophages are immune cells that phagocytose and remove dust, bacteria and allergens. According to Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages published on Thorax, e-cigarette vapor damages the function of alveolar macrophages. Researchers believe that this suggests that the dangers of e-cigarettes may be greater than previously thought.

    However, the debate surrounding e-cigarettes is still difficult to determine. Previously, British researchers believed that e-cigarettes were less harmful to the body than traditional cigarettes. In addition, the attitudes of the regulatory authorities in different countries are also different. The United Kingdom has approved the sale of some e-cigarette products as cessation aids, but the US has adopted a cautious attitude, especially in the use of e-cigarettes by young people.

New findings in inhibiting breast cancer infiltration

Posted by star on 2018-09-03 19:42:53


    Usually most breast tumors begin in the inner cells of the breast duct, which are surrounded by myoepithelial cells. Previously, scientists believe that the cell layer of myoepithelial cells is a static barrier to prevent cancer infiltration.

    More recently, experiments in laboratory-cultured mouse tissues have shown that the cell layer around the breast duct can reach out and capture escaped cancer cells to prevent their spread in the body. This suggests that the cell layer of myoepithelial cells is an active defense mechanism that inhibits breast cancer metastasis. The paper of Myoepithelial cells are a dynamic barrier to epithelial dissemination was published online in the Journal of Cell Biology.

    It is known that the myoepithelial layer is clinically used to diagnose differential restrictive breast cancer and invasive breast cancer in humans. If breast cancer cells break through the myoepithelial layer, the result is a so-called invasive cancer, which has a higher recurrence rate and requires more aggressive treatment.

    In the study, the researchers engineered cells removed from the inner mammary gland to produce the protein Twist1, which acts by altering gene expression and is involved in cancer metastasis of multiple tumor types.

    Surprisingly, the researchers found that when infiltrating Twist1 cells broke through the myoepithelial layer, myoepithelial cells were able to capture these escaped cells. In a total of 114 observations, 92% of the time it was pulled back into the mammary duct.

    Wuhan EIAab Science Co., Ltd has developed Twist1 kit. Welcome scientific research workers to choose and purchas......

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